Biocatalytic synthesis of coumarin S-glycosides: towards non-cytotoxic probes for biomedical imaging and sensing - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Molecules Année : 2024

Biocatalytic synthesis of coumarin S-glycosides: towards non-cytotoxic probes for biomedical imaging and sensing

Résumé

This study unveils an innovative method for synthesizing coumarin S-glycosides, employing original biocatalysts able to graft diverse carbohydrate structures onto 7-mercapto-4-methyl-coumarin in one-pot reactions. The fluorescence properties of the generated thio-derivatives were assessed, providing valuable insights into their potential applications in biological imaging or sensing. In addition, the synthesized compounds exhibited no cytotoxicity across various human cell lines. This research presents a promising avenue for the development of coumarin S-glycosides, paving the way for their application in diverse biomedical research areas.

Domaines

Chimie
Fichier principal
Vignette du fichier
molecules-29-01322-with-cover.pdf (925.25 Ko) Télécharger le fichier
Origine : Fichiers éditeurs autorisés sur une archive ouverte
Licence : CC BY - Paternité

Dates et versions

hal-04510330 , version 1 (18-03-2024)

Licence

Paternité

Identifiants

Citer

Nastassja Burrini, Arnaud Pâris, Guillaume Collet, Pierre Lafite, Richard Daniellou. Biocatalytic synthesis of coumarin S-glycosides: towards non-cytotoxic probes for biomedical imaging and sensing. Molecules, 2024, 29 (6), pp.1322. ⟨10.3390/molecules29061322⟩. ⟨hal-04510330⟩
2 Consultations
1 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More