“Hemispheric pilocytic astrocytoma” revisited: A comprehensive clinicopathological and molecular series emphasizing their overlap with other glioneuronal tumors - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Journal of Neuropathology and Experimental Neurology Année : 2024

“Hemispheric pilocytic astrocytoma” revisited: A comprehensive clinicopathological and molecular series emphasizing their overlap with other glioneuronal tumors

Cassandra Mariet
  • Fonction : Auteur
Jacques Grill
Yassine Ajlil
  • Fonction : Auteur
David Castel
  • Fonction : Auteur
Volodia Dangouloff-Ros
  • Fonction : Auteur
Nathalie Boddaert
  • Fonction : Auteur
Alexandra Meurgey
  • Fonction : Auteur
Daniel Pissaloux
  • Fonction : Auteur
Raphaël Saffroy
  • Fonction : Auteur
Stéphanie Puget
  • Fonction : Auteur
Thomas Blauwblomme
Kévin Beccaria
Lauren Hasty
  • Fonction : Auteur
Valérie Rigau
Thomas Roujeau
  • Fonction : Auteur
Aude Aline-Fardin
  • Fonction : Auteur
Fabrice Chrétien
  • Fonction : Auteur
Alice Métais
  • Fonction : Auteur
Pascale Varlet
  • Fonction : Auteur
Arnault Tauziède-Espariat
  • Fonction : Auteur

Résumé

Abstract Pilocytic astrocytomas (PA) typically exhibit distinct clinical, radiological, histopathological, and genetic features. DNA-methylation profiling distinguishes PA according to their location (infratentorial, midline, hemispheric, or spinal). In the hemispheric location, distinguishing PA from glioneuronal tumors remains a common diagnostic challenge for neuropathologists. Furthermore, the current version of the DKFZ classifier seems to have difficulty separating them from gangliogliomas. In this study, after central radiological review, we identified a histopathologically defined set of PA (histPA, n = 11) and a cohort of DNA-methylation defined PA (mcPA, n = 11). Nine out of the 11 histPA matched the methylation class of hemispheric PA, whereas 2 cases were classified at the end of the study as dysembryoplastic neuroepithelial tumors. Similarly, the mcPA cohort contained tumors mainly classified as PA (7/11), but 4 cases were classified as glioneuronal. The analysis of the 16 tumors with an integrated diagnosis of PA revealed that they affect mainly children with a wide spectrum of radiological, histopathological (i.e. a predominantly diffuse growth pattern), and genetic characteristics (large range of mitogen-activated protein kinase alterations). Based on these results, we consider hemispheric PA to be different from their counterparts in other locations and to overlap with other glioneuronal tumors, reinforcing the necessity of interpreting all data to obtain an accurate diagnosis.
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Dates et versions

hal-04508893 , version 1 (18-03-2024)

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Cassandra Mariet, Jacques Grill, Yassine Ajlil, David Castel, Volodia Dangouloff-Ros, et al.. “Hemispheric pilocytic astrocytoma” revisited: A comprehensive clinicopathological and molecular series emphasizing their overlap with other glioneuronal tumors. Journal of Neuropathology and Experimental Neurology, 2024, 83 (2), pp.115-124. ⟨10.1093/jnen/nlad111⟩. ⟨hal-04508893⟩
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