Skin autofluorescence of advanced glycation end-products relates to new cardiovascular events in type 2 diabetes: A longitudinal observational study - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Diabetes & Metabolism Année : 2024

Skin autofluorescence of advanced glycation end-products relates to new cardiovascular events in type 2 diabetes: A longitudinal observational study

Fadi Alkhami
  • Fonction : Auteur
Gauthier Borderie
  • Fonction : Auteur
Ninon Foussard
  • Fonction : Auteur
Alice Larroumet
  • Fonction : Auteur
Laurence Blanco
  • Fonction : Auteur
Marie-Amelie Barbet-Massin
  • Fonction : Auteur
Amandine Ferriere
  • Fonction : Auteur
Claire Ducos
  • Fonction : Auteur
Kamel Mohammedi
  • Fonction : Auteur
Sami Fawaz
  • Fonction : Auteur
Thierry Couffinhal
  • Fonction : Auteur

Résumé

BACKGROUND: Cardiovascular disease is frequent in type 2 diabetes mellitus (T2DM). We investigated the relationship between skin autofluorescence (SAF) of advanced glycation end-products and later cardiovascular events (CVEs) in patients with T2DM. RESEARCH DESIGN AND METHODS: We conducted a retrospective analysis of 504 patients hospitalized for uncontrolled and/or complicated T2DM between 2009 and 2017. SAF was measured using an AGE-Reader. Participants were followed up from admission to December 2020, for the onset of a CVE (myocardial infarction, stroke, revascularization procedures or cardiovascular death). The relationship between SAF and CVE was analyzed by multivariable Cox regression. Log-rank curves were used to compare CVE-free survival in patients whose SAF at admission was above versus below the whole-population median. The analysis was repeated in subjects without/with macroangiopathy (defined as myocardial infarction, stroke, peripheral revascularization) at baseline. FINDINGS: During 54 months of follow-up, 69 (13.7%) patients had a CVE. Baseline SAF was significantly higher in patients with T2DM who later experienced a CVE (2.89 ± 0.70 arbitrary units versus 2.64 ± 0.62 in others, P = 0.002). This relationship was significant after adjusting for age, sex, conventional risk factors (diabetes duration, HbA1c, arterial hypertension, dyslipidemia, smoking, body mass index), vascular complications, C-reactive protein, and treatments for diabetes. The CVE-free survival curves differed between subjects whose SAF was above the whole-population median (log-rank: P = 0.002) and those whose SAF was above the macroangiopathy-free sub-population median (log-rank: P = 0.016). CONCLUSION: SAF of advanced glycation end-products was related to a higher incidence of later CVE in patients with T2DM.
Fichier non déposé

Dates et versions

hal-04504400 , version 1 (14-03-2024)

Identifiants

Citer

Fadi Alkhami, Gauthier Borderie, Ninon Foussard, Alice Larroumet, Laurence Blanco, et al.. Skin autofluorescence of advanced glycation end-products relates to new cardiovascular events in type 2 diabetes: A longitudinal observational study. Diabetes & Metabolism, 2024, 50 (2), pp.101524. ⟨10.1016/j.diabet.2024.101524⟩. ⟨hal-04504400⟩

Collections

U1219
3 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More