Integrating [18F]-Fluorodeoxyglucose Positron Emission Tomography with Computed Tomography with Radiation Therapy and Immunomodulation in Precision Therapy for Solid Tumors - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Cancers Année : 2023

Integrating [18F]-Fluorodeoxyglucose Positron Emission Tomography with Computed Tomography with Radiation Therapy and Immunomodulation in Precision Therapy for Solid Tumors

Conor Prendergast
  • Fonction : Auteur
Egesta Lopci
Romain-David Seban
Dorine de Jong
Samy Ammari
Sanjay Aneja
Abin Sajan
  • Fonction : Auteur
Mary Salvatore
  • Fonction : Auteur
Kathleen Cappacione
  • Fonction : Auteur
Lawrence Schwartz
  • Fonction : Auteur
Eric Deutsch
  • Fonction : Auteur
Laurent Dercle

Résumé

[18F]-FDG positron emission tomography with computed tomography (PET/CT) imaging is widely used to enhance the quality of care in patients diagnosed with cancer. Furthermore, it holds the potential to offer insight into the synergic effect of combining radiation therapy (RT) with immuno-oncological (IO) agents. This is achieved by evaluating treatment responses both at the RT and distant tumor sites, thereby encompassing the phenomenon known as the abscopal effect. In this context, PET/CT can play an important role in establishing timelines for RT/IO administration and monitoring responses, including novel patterns such as hyperprogression, oligoprogression, and pseudoprogression, as well as immune-related adverse events. In this commentary, we explore the incremental value of PET/CT to enhance the combination of RT with IO in precision therapy for solid tumors, by offering supplementary insights to recently released joint guidelines.

Domaines

Cancer

Dates et versions

hal-04501559 , version 1 (12-03-2024)

Identifiants

Citer

Conor Prendergast, Egesta Lopci, Romain-David Seban, Dorine de Jong, Samy Ammari, et al.. Integrating [18F]-Fluorodeoxyglucose Positron Emission Tomography with Computed Tomography with Radiation Therapy and Immunomodulation in Precision Therapy for Solid Tumors. Cancers, 2023, 15 (21), pp.5179. ⟨10.3390/cancers15215179⟩. ⟨hal-04501559⟩
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