Prognostic factors in neuroendocrine carcinoma: biological markers are more useful than histomorphological markers - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Scientific Reports Année : 2017

Prognostic factors in neuroendocrine carcinoma: biological markers are more useful than histomorphological markers

Résumé

Abstract Gastroenteropancreatic neuroendocrine carcinomas (GEP-NEC) are a very aggressive type of cancer, for which prognostic factors are lacking. We analysed clinical and histomorphological prognostic markers of overall survival (OS), completed with a record of biological and haematological data of patients diagnosed between December 2002 and December 2015. The median OS was 16 months (95% CI 13.9–18.1). After univariate analysis, performance status (PS) ≥ 2 and stage IV were associated with a worse outcome (9 months and 14 months, respectively), as well as patients with lactate dehydrogenase (LDH) and aspartate aminotransferase (AST) levels ≥ 2 ULN (9 months and 8 months, respectively). After multivariate analysis, LDH and AST levels were the only factors that remained significantly associated with better survival: HR 0.36 ( p = 0.04) and 0.31 ( p = 0.03), respectively. When patients had elevated LDH and AST levels, OS was 20 months, when they had high LDH or AST levels, 13 months and 8 months in the group with low LDH and AST levels ( p < 0.001). Therefore, biological data appeared to be more relevant prognostic factors than usual factors described in other studies (PS, stage, and Ki-67). Considering LDH and AST levels at diagnosis could help physicians to predict survival and to stratify patients for clinical trials.

Dates et versions

hal-04500093 , version 1 (11-03-2024)

Identifiants

Citer

Patricia Freis, Emmanuelle Graillot, Pascal Rousset, Valérie Hervieu, Laurence Chardon, et al.. Prognostic factors in neuroendocrine carcinoma: biological markers are more useful than histomorphological markers. Scientific Reports, 2017, 7 (1), pp.40609. ⟨10.1038/srep40609⟩. ⟨hal-04500093⟩
3 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More