SYK-3BP2 Pathway Activity in Parenchymal and Myeloid Cells Is a Key Pathogenic Factor in Metabolic Steatohepatitis - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Cellular and Molecular Gastroenterology and Hepatology Année : 2022

SYK-3BP2 Pathway Activity in Parenchymal and Myeloid Cells Is a Key Pathogenic Factor in Metabolic Steatohepatitis

Résumé

Spleen tyrosine kinase (SYK) signaling pathway regulates critical processes in innate immunity, but its role in parenchymal cells remains elusive in chronic liver diseases. We investigate the relative contribution of SYK and its substrate c-Abl Src homology 3 domain-binding protein-2 (3BP2) in both myeloid cells and hepatocytes in the onset of metabolic steatohepatitis.

Mots clés

Fichier principal
Vignette du fichier
S2352345X21001715.pdf (1.35 Mo) Télécharger le fichier
Origine Fichiers produits par l'(les) auteur(s)

Dates et versions

hal-04496274 , version 1 (22-07-2024)

Licence

Identifiants

Citer

Carmelo Luci, Elodie Vieira, Manon Bourinet, Déborah Rousseau, Stéphanie Bonnafous, et al.. SYK-3BP2 Pathway Activity in Parenchymal and Myeloid Cells Is a Key Pathogenic Factor in Metabolic Steatohepatitis. Cellular and Molecular Gastroenterology and Hepatology, 2022, 13 (1), pp.173-191. ⟨10.1016/j.jcmgh.2021.08.004⟩. ⟨hal-04496274⟩
5 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Mastodon Facebook X LinkedIn More