Roles of innate lymphoid cells in metabolic and alcohol-associated liver diseases - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue JHEP Reports Innovation in Hepatology Année : 2024

Roles of innate lymphoid cells in metabolic and alcohol-associated liver diseases

Résumé

Innate lymphoid cells (ILCs) have been identified as potent regulators of inflammation, cell death and wound healing, which are the main biological processes involved in the progression of chronic liver disease. Obesity and chronic alcohol consumption are the leading contributors to chronic liver diseases in developed countries, due to inappropriate lifestyles. In particular, inflammation is a key factor in these liver abnormalities and promotes the development of more severe lesions such as fibrosis, cirrhosis and hepatocellular carcinoma. Opposite roles of ILC subsets have been described in the development of chronic liver disease, depending on the stage and aetiology of the disease. The heterogeneous family of ILCs encompasses cytotoxic natural killer cells, the cytokine-producing type 1, 2 and 3 ILCs and lymphoid tissue inducer cells. Dysfunction of these immune cells provokes uncontrolled inflammation and tissue damage, which are the basis for tumour development. In this review, we provide an overview of the recent and putative roles of ILC subsets in obesity and alcohol-associated liver diseases, which are currently the major contributors to end-stage liver complications such as fibrosis/cirrhosis and hepatocellular carcinoma.

Dates et versions

hal-04495843 , version 1 (08-03-2024)

Identifiants

Citer

Manon Bourinet, Rodolphe Anty, Philippe Gual, Carmelo Luci. Roles of innate lymphoid cells in metabolic and alcohol-associated liver diseases. JHEP Reports Innovation in Hepatology, 2024, 6 (2), pp.100962. ⟨10.1016/j.jhepr.2023.100962⟩. ⟨hal-04495843⟩
4 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More