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Article Dans Une Revue Scientific Reports Année : 2024

SARS-CoV-2 infection prevalence and associated factors among primary healthcare workers in France after the third COVID-19 wave

Dorine Decarreaux
  • Fonction : Auteur
Laura Di Domenico
  • Fonction : Auteur
Chiara Sabbatini
  • Fonction : Auteur
Pol Prévot-Monsacre
  • Fonction : Auteur
Toscane Fourié
  • Fonction : Auteur
Paola Mariela Saba Villarroel
  • Fonction : Auteur
Stephane Priet
  • Fonction : Auteur
Hélène Blanché
  • Fonction : Auteur
Jean-Marc Sebaoun
  • Fonction : Auteur
Jean-François Deleuze
  • Fonction : Auteur
Clément Turbelin
  • Fonction : Auteur
Louise Rossignol
  • Fonction : Auteur
Andréas Werner
  • Fonction : Auteur
Fabienne Kochert
  • Fonction : Auteur
Brigitte Grosgogeat
  • Fonction : Auteur
Pascaline Rabiega
  • Fonction : Auteur
Julien Laupie
  • Fonction : Auteur
Nathalie Abraham
  • Fonction : Auteur
Harold Noël
  • Fonction : Auteur
Sylvie van der Werf
  • Fonction : Auteur
Vittoria Colizza
  • Fonction : Auteur
Fabrice Carrat
  • Fonction : Auteur
Remi Charrel
  • Fonction : Auteur
Xavier de Lamballerie
  • Fonction : Auteur
Thierry Blanchon
  • Fonction : Auteur
Alessandra Falchi
  • Fonction : Auteur

Résumé

Abstract Data on the SARS-CoV-2 infection among primary health care workers (PHCWs) are scarce but essential to reflect on policy regarding prevention and control measures. We assessed the prevalence of PHCWs who have been infected by SARS-CoV-2 in comparison with modeling from the general population in metropolitan France, and associated factors. A cross-sectional study was conducted among general practitioners (GPs), pediatricians, dental and pharmacy workers in primary care between May and August 2021. Participants volunteered to provide a dried-blood spot for SARS-CoV-2 antibody assessment and completed a questionnaire. The primary outcome was defined as the detection of infection-induced antibodies (anti-nucleocapsid IgG, and for non-vaccinees: anti-Spike IgG and neutralizing antibodies) or previous self-reported infection (positive RT-qPCR or antigenic test, or positive ELISA test before vaccination). Estimates were adjusted using weights for representativeness and compared with prediction from the general population. Poisson regressions were used to quantify associated factors. The analysis included 1612 PHCWs. Weighted prevalences were: 31.7% (95% CI 27.5–36.0) for GPs, 28.7% (95% CI 24.4–33.0) for pediatricians, 25.2% (95% CI 20.6–31.0) for dentists, and 25.5% (95% CI 18.2–34.0) for pharmacists. Estimates were compatible with model predictions for the general population. PHCWs more likely to be infected were: GPs compared to pharmacist assistants (adjusted prevalence ratio [aPR] = 2.26; CI 95% 1.01–5.07), those living in Île-de-France (aPR = 1.53; CI 95% 1.14–2.05), South-East (aPR = 1.57; CI 95% 1.19–2.08), North-East (aPR = 1.81; CI 95% 1.38–2.37), and those having an unprotected contact with a COVID-19 case within the household (aPR = 1.48; CI 95% 1.22–1.80). Occupational factors were not associated with infection. In conclusion, the risk of SARS-CoV-2 exposure for PHCWs was more likely to have occurred in the community rather than at their workplace.

Dates et versions

hal-04494616 , version 1 (07-03-2024)

Identifiants

Citer

Marie Pouquet, Dorine Decarreaux, Laura Di Domenico, Chiara Sabbatini, Pol Prévot-Monsacre, et al.. SARS-CoV-2 infection prevalence and associated factors among primary healthcare workers in France after the third COVID-19 wave. Scientific Reports, 2024, 14 (1), pp.5418. ⟨10.1038/s41598-024-55477-9⟩. ⟨hal-04494616⟩
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