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Article Dans Une Revue Endocrine Connections Année : 2020

Post first-line dacarbazine or temozolomide in neuroendocrine carcinoma

Thomas Couronne
  • Fonction : Auteur
Paul Girot
  • Fonction : Auteur
Julien Hadoux
  • Fonction : Auteur
Thierry Lecomte
  • Fonction : Auteur
Alice Durand
  • Fonction : Auteur
Caroline Fine
  • Fonction : Auteur
Katia Vandevoorde
  • Fonction : Auteur
Catherine Lombard-Bohas
  • Fonction : Auteur

Résumé

Objective First-line chemotherapy in metastatic neuroendocrine carcinomas (NECs) is based on etoposide and platinum. However, there is no standard concerning second-line treatment. The objective of this study was to evaluate efficacy and tolerance of dacarbazine or temozolomide in metastatic digestive NEC as post first-line treatment. Material and methods This study included patients with a metastatic NEC of digestive or unknown primary site. All patients received platinum-etoposide as first-line chemotherapy. Primary endpoint was progression-free survival (PFS). Secondary endpoints were clinical/morphological responses, toxicity, and overall survival (OS). Results Twenty-seven patients were included: 17 received dacarbazine and 10 temozolomide as post-first line treatments. Median PFS was 3.0 (95%CI (2.2;3.7)) months. There was no significant difference between dacarbazine and temozolomide on PFS. Clinical and morphological responses were found in 12 and 9 patients, respectively. Median OS was 7.2 (95%CI (2.2;12.2)) months. The toxicity profile was that expected with such treatments. Conclusion LV5FU2-dacarbazine or temozolomide-capecitabine chemotherapies allow a temporary clinical response for almost half of patients and/or a morphological response for a third of patients.

Dates et versions

hal-04492751 , version 1 (06-03-2024)

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Paternité - Pas d'utilisation commerciale - Pas de modification

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Thomas Couronne, Paul Girot, Julien Hadoux, Thierry Lecomte, Alice Durand, et al.. Post first-line dacarbazine or temozolomide in neuroendocrine carcinoma. Endocrine Connections, 2020, 9 (6), pp.498-505. ⟨10.1530/ec-20-0192⟩. ⟨hal-04492751⟩
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