Natural Bioactive Compounds against Schistosoma haematobium and Schistosoma mansoni
Composés naturels bioactifs contre Schistosoma haematobium et Schistosoma mansoni
Résumé
Aim: This documentary review aimed to make a synthesis of bioactive plants or natural compounds
on schistosomes. We carried out a review from 2000 to 2022, oriented towards the plants in order
to search natural compounds bioactive on schistosomes which can be a great contribution for new
drugs discovering.
Terms such as “schistosomiasis and medicinal plants”, “natural anti-schistosome compounds”,
“phytochemical screening”, “bioactive compounds on schistosomes” were used for the
online literature search through the following sites: PubMed; Google Scholar; ScienceDirect and
Hinari.
Results: There are many plants already used for the traditional treatment of schistosomiasis. This
review found nearly 72 families of plants belonging to 228 botanical species have been listed. Some
of these have been studied in vitro / in vivo and preliminary results have shown their
schistosomicidal properties. Moreover, the results of qualitative phytochemical screening and
toxicity testing of these natural compounds provide hope for new drug discoveries.
Conclusion: Even if plants efficacy is proven, we need more in-depth investigations to determine
their chemical components in order to minimize the undesirable effects and to guarantee their
safety by assessing their toxicity.
Domaines
Sciences du Vivant [q-bio]
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