An International Registry of Peritoneal Carcinomatosis from Appendiceal Goblet Cell Carcinoma Treated with Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue World Journal of Surgery Année : 2022

An International Registry of Peritoneal Carcinomatosis from Appendiceal Goblet Cell Carcinoma Treated with Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy

Frederic Mercier
Guillaume Passot
  • Fonction : Auteur
Pierre‐emmanuel Bonnot
  • Fonction : Auteur
Peter Cashin
  • Fonction : Auteur
Wim Ceelen
  • Fonction : Auteur
Evelyne Decullier
  • Fonction : Auteur
Laurent Villeneuve
  • Fonction : Auteur
Edward Levine
  • Fonction : Auteur
Olivier Glehen
  • Fonction : Auteur

Résumé

Abstract Purpose Peritoneal carcinomatosis from appendiceal goblet cell carcinoma (A‐GCC) is a rare and aggressive form of appendiceal tumor. Cytoreductive surgery (CRS) and hyperthermic intra peritoneal chemotherapy (HIPEC) was reported as an interesting alternative regarding survival compared to surgery without HIPEC and/or systemic chemotherapy. Our aim was to evaluate the impact of CRS and HIPEC for patients presenting A‐GCC through an international registry. Methods A prospective multicenter international database was retrospectively searched to identify all patients with A‐GCC tumor and peritoneal metastases who underwent CRS and HIPEC through the Peritoneal Surface Oncology Group International (PSOGI). The post‐operative complications, long‐term results, and principal prognostic factors were analyzed. Results The analysis included 83 patients. After a median follow‐up of 47 months, the median overall survival (OS) was 34.6 months. The 3‐ and 5‐year OS was 48.5% and 35.7%, respectively. Patients who underwent complete macroscopic CRS had a significantly better survival than those treated with incomplete CRS. The 5‐year OS was 44% and 0% for patients who underwent complete, and incomplete CRS, respectively (HR 9.65, p < 0.001). Lymph node involvement and preoperative chemotherapy were also predictive of a worse prognosis. There were 3 postoperative deaths, and 30% of the patients had major complications. Conclusion CRS and HIPEC may increase long‐term survival in selected patients with peritoneal metastases of A‐GCC origin, especially when complete CRS is achieved. Ideally, randomized control trials or more retrospective data are needed to confirm CRS and HIPEC as the gold standard in this pathology.

Dates et versions

hal-04490255 , version 1 (05-03-2024)

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Paternité - Pas d'utilisation commerciale - Pas de modification

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Citer

Frederic Mercier, Guillaume Passot, Pierre‐emmanuel Bonnot, Peter Cashin, Wim Ceelen, et al.. An International Registry of Peritoneal Carcinomatosis from Appendiceal Goblet Cell Carcinoma Treated with Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy. World Journal of Surgery, 2022, 46 (6), pp.1336-1343. ⟨10.1007/s00268-022-06498-w⟩. ⟨hal-04490255⟩
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