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Article Dans Une Revue Endocrine-Related Cancer Année : 2023

COVID-19 in patients with neuroendocrine neoplasms: 2-year results of the INTENSIVE study

Nicola Fazio
Lorenzo Gervaso
Thorvardur Halfdanarson
Mohamad Sonbol
  • Fonction : Auteur
Rachel Eiring
  • Fonction : Auteur
Sara Pusceddu
  • Fonction : Auteur
Natalie Prinzi
  • Fonction : Auteur
Benedetta Lombardi Stocchetti
  • Fonction : Auteur
Simona Grozinsky-Glasberg
David Gross
  • Fonction : Auteur
Patrick Robelin
  • Fonction : Auteur
Catherine Lombard-Bohas
  • Fonction : Auteur
Samuele Frassoni
  • Fonction : Auteur
Vincenzo Bagnardi
  • Fonction : Auteur
Lorenzo Antonuzzo
  • Fonction : Auteur
Clotilde Sparano
Sara Massironi
Fabio Gelsomino
  • Fonction : Auteur
Alberto Bongiovanni
  • Fonction : Auteur
Nicoletta Ranallo
  • Fonction : Auteur
Salvatore Tafuto
  • Fonction : Auteur
Maura Rossi
  • Fonction : Auteur
Mauro Cives
  • Fonction : Auteur
Ibrahim Rasul Kakil
  • Fonction : Auteur
Hytam Hamid
  • Fonction : Auteur
Alessandra Chirco
  • Fonction : Auteur
Michela Squadroni
  • Fonction : Auteur
Anna La Salvia
  • Fonction : Auteur
Jorge Hernando
  • Fonction : Auteur
Johannes Hofland
Anna Koumarianou
  • Fonction : Auteur
Sabrina Boselli
  • Fonction : Auteur
Darina Tamayo
  • Fonction : Auteur
Cristina Mazzon
  • Fonction : Auteur
Manila Rubino
  • Fonction : Auteur
Francesca Spada
  • Fonction : Auteur

Résumé

We conducted a retrospective/prospective worldwide study on patients with neuroendocrine neoplasms (NENs) and a molecularly proven SARS-CoV-2 positivity. Preliminary results regarding 85 patients of the INTENSIVE study have been published in 2021. Now we are reporting the 2-year analysis.Here, we are reporting data from consecutive patients enrolled between 1 June 2020, and 31 May 2022. Among the 118 contacted centers, 25 were active to enroll and 19 actively recruiting at the time of data cut-off for a total of 280 patients enrolled. SARS-CoV-2 positivity occurred in 47.5% of patients in 2020, 35.1% in 2021, and 17.4% in 2022. The median age for COVID-19 diagnosis was 60 years. Well-differentiated tumors, non-functioning, metastatic stage, and gastroenteropancreatic (GEP) primary sites represented most of the NENs. COVID-19-related pneumonia occurred in 22.8% of the total, with 61.3% of them requiring hospitalization; 11 patients (3.9%) needed sub-intensive or intensive care unit therapies and 14 patients died (5%), in 11 cases (3.9%) directly related to COVID-19. Diabetes mellitus and age at COVID-19 diagnosis > 70 years were significantly associated with COVID-19 mortality, whereas thoracic primary site with COVID-19 morbidity. A significant decrease in both hospitalization and pneumonia occurred in 2022 vs 2020. In our largest series of NEN patients with COVID-19, the NEN population is similar to the general population of patients with NEN regardless of COVID-19. However, older age, non-GEP primary sites and diabetes mellitus should be carefully considered for increased COVID-19 morbidity and mortality. Relevant information could be derived by integrating our results with NENs patients included in other cancer patients with COVID-19 registries.
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Dates et versions

hal-04489844 , version 1 (05-03-2024)

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Nicola Fazio, Lorenzo Gervaso, Thorvardur Halfdanarson, Mohamad Sonbol, Rachel Eiring, et al.. COVID-19 in patients with neuroendocrine neoplasms: 2-year results of the INTENSIVE study. Endocrine-Related Cancer, 2023, 30 (6), ⟨10.1530/erc-22-0395⟩. ⟨hal-04489844⟩
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