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Poster De Conférence Année : 2022

Sampling of French cervid populations for genetic analysis of susceptibility towards chronic wasting disease

Résumé

Chronic wasting disease (CWD), known since 1967 in North America, appeared in 2016 in North Europe, affecting different species of deer such as reindeer or elk. CWD is a highly transmissible prion disease that might weaken the European cervid populations. Genetic susceptibility towards prion diseases is mostly determined by the prion protein gene sequence as exemplified in humans, cattle and sheep. We started to investigate for the first time the polymorphism of this gene in French red deer and roe deer populations, as part of the ANR EU-CWD project (2021-2025). A national sampling of red deer and roe deer populations was carried out during the 2020-2021 and 2021-2022 winters, with the collaboration of 32 departmental hunting federations, as well as 6 study areas of French Biodiversity Agency (Figure 1). This monitoring was based on the origins and geographical locations of these wild animals in France Muscle samples were taken from the cervid,preserved in alcohol before DNA extraction and Prnp coding sequence analysis. Currently 248 samples have been analyzed and no new allele observed. These data confirmed the already highlighted surprising Prnp roe deer genetic homogeneity. A total of 1100 samples will be sequenced, and should provide us a detailed analysis of the range of cervid Prnp polymorphisms (including their geographic distribution) present in French red and roe deer populations. The aim of this study is to map the Prnp genetic distribution of French cervids and to estimate their susceptibility towards CWD.
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Dates et versions

hal-04489703 , version 1 (05-03-2024)

Identifiants

  • HAL Id : hal-04489703 , version 1

Citer

Emma Meloni, Anne van de Wiele, Maryline Pellerin, Christine Saint-Andrieux, Aurélie Barboiron, et al.. Sampling of French cervid populations for genetic analysis of susceptibility towards chronic wasting disease. Nordic Congress of Wildlife Research, Sep 2022, Uppsala (Suède), Sweden. . ⟨hal-04489703⟩
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