2- or 3-imidazolines as carbapenemases inhibitors
Résumé
The invention relates to prepn. of 3-imidazolines of formula (I) as inhibitors of carbapenemases. Compds. I wherein Ar1, Ar2 and Ar3 are identical or different and are independently (un)substituted mono or polycyclic C5-12 aryl or mono or polycyclic C3-12 heteroaryl; R4 is present when the bond between the carbon 1 and the nitrogen atom is a single bond and is absent when the bond between the carbon 1 and the nitrogen atom is a double bond; ; R4a is H, or C1-6 alkyl, etc,; etc., are claimed. Compds. I are useful in antibiotic therapies, in particular as inhibitors of carbapenemases. They are also useful as antibiotics themselves. The further relates to conjugates of I with known antibiotics.