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Brevet Année : 2018

2- or 3-imidazolines as carbapenemases inhibitors

Résumé

The invention relates to prepn. of 3-imidazolines of formula (I) as inhibitors of carbapenemases. Compds. I wherein Ar1, Ar2 and Ar3 are identical or different and are independently (un)substituted mono or polycyclic C5-12 aryl or mono or polycyclic C3-12 heteroaryl; R4 is present when the bond between the carbon 1 and the nitrogen atom is a single bond and is absent when the bond between the carbon 1 and the nitrogen atom is a double bond; ; R4a is H, or C1-6 alkyl, etc,; etc., are claimed. Compds. I are useful in antibiotic therapies, in particular as inhibitors of carbapenemases. They are also useful as antibiotics themselves. The further relates to conjugates of I with known antibiotics.
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Dates et versions

hal-04489573 , version 1 (05-03-2024)

Identifiants

  • HAL Id : hal-04489573 , version 1

Citer

Kevin Cariou, Robert H. Dodd, Eugenie Romero, Mohamed Benchekroun, Bogdan I. Iorga, et al.. 2- or 3-imidazolines as carbapenemases inhibitors. France, Patent n° : WO/2018/162670. 2018. ⟨hal-04489573⟩
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