Article Dans Une Revue Cancer Research Année : 2009

Senescence-Associated Oxidative DNA Damage Promotes the Generation of Neoplastic Cells

Peter Ostoich
  • Fonction : Auteur
Laurence Duprez
  • Fonction : Auteur
Nicolas Malaquin
  • Fonction : Auteur
Marjan Ashtari
  • Fonction : Auteur

Résumé

Abstract Studies on human fibroblasts have led to viewing senescence as a barrier against tumorigenesis. Using keratinocytes, we show here that partially transformed and tumorigenic cells systematically and spontaneously emerge from senescent cultures. We show that these emerging cells are generated from senescent cells, which are still competent for replication, by an unusual budding-mitosis mechanism. We further present data implicating reactive oxygen species that accumulate during senescence as a potential mutagenic motor of this post-senescence emergence. We conclude that senescence and its associated oxidative stress could be a tumor-promoting state for epithelial cells, potentially explaining why the incidence of carcinogenesis dramatically increases with advanced age. [Cancer Res 2009;69(20):7917–24]

Dates et versions

hal-04488967 , version 1 (04-03-2024)

Identifiants

Citer

Karo Gosselin, Sébastien Martien, Albin Dr Pourtier, Chantal Vercamer, Peter Ostoich, et al.. Senescence-Associated Oxidative DNA Damage Promotes the Generation of Neoplastic Cells. Cancer Research, 2009, 69 (20), pp.7917-7925. ⟨10.1158/0008-5472.CAN-08-2510⟩. ⟨hal-04488967⟩
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