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Communication Dans Un Congrès Année : 2024

A digital hardware system for real-time biorealistic stimulation on in vitro cardiomyocytes

Pierre-Marie Faure
  • Fonction : Auteur
  • PersonId : 1320662
Agnès Tixier-Mita
  • Fonction : Auteur
  • PersonId : 1320664
Timothée Levi

Résumé

Every year, cardiovascular disease causes millions of deaths worldwide. These diseases involve complex mechanisms that are difficult to study. To remedy this problem, we propose to develop a heart-brain platform capable of reproducing the mechanisms involved in generating the heartbeat. The platform will be designed to operate in real-time, with the most economical and integrated design possible. To achieve this, we are implementing highly biologically coherent cellular models on FPGA, which we interconnect with in vitro cell cultures. In our case, we are using the Maltsev-Lakatta cell model, which describes the behavior of the pacemaker cells responsible for the heart rhythm, to stimulate a cardiomyocyte culture.
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Dates et versions

hal-04487645 , version 1 (04-03-2024)

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  • HAL Id : hal-04487645 , version 1

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Pierre-Marie Faure, Agnès Tixier-Mita, Timothée Levi. A digital hardware system for real-time biorealistic stimulation on in vitro cardiomyocytes. ISAROB, Jan 2024, Beppu, Japan. ⟨hal-04487645⟩
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