Longitudinal Associations Between ATPase Inhibitory Factor 1, Growth Differentiation Factor-15, and Nutritional Status in Older Adults From the MAPT Study - Archive ouverte HAL Access content directly
Journal Articles Journals of Gerontology Series A: Biological Sciences and Medical Sciences Year : 2024

Longitudinal Associations Between ATPase Inhibitory Factor 1, Growth Differentiation Factor-15, and Nutritional Status in Older Adults From the MAPT Study

Laetitia Lengelé (1) , Yves Rolland (2, 3, 1) , Laurent Martinez (4) , Sophie Guyonnet (2, 3, 1) , Angelo Parini (4) , Alexandre Lucas (4) , Bruno Vellas (2, 3, 1) , Philipe de Souto Barreto (3, 2, 1) , Sophie Guyonnet (2, 3) , Isabelle Carrié (1) , Lauréane Brigitte , Catherine Faisant , Françoise Lala , Julien Delrieu (5, 2, 3) , Hélène Villars (2, 6, 3) , Emeline Combrouze , Carole Badufle , Audrey Zueras , Sandrine Andrieu (7, 1, 3) , Christelle Cantet (1, 2, 3) , Christophe Morin (8, 9) , Gabor Abellan van Kan (2, 3) , Charlotte Dupuy (10) , Céline Caillaud (11) , Pierre-Jean Ousset (1, 2, 3) , Françoise Lala , Sherry Willis (12) , Sylvie Belleville (13) , Brigitte Gilbert (13) , Francine Fontaine , Jean-François Dartigues (14) , Isabelle Marcet , Fleur Delva (14) , Alexandra Foubert , Sandrine Cerda , Corinne Costes , Olivier Rouaud , Patrick Manckoundia , Valérie Quipourt , Sophie Marilier , Evelyne Franon , Lawrence Bories , Marie-Laure Pader , Marie-France Basset , Bruno Lapoujade , Valérie Faure , Michael Li Yung Tong , Christine Malick-Loiseau , Evelyne Cazaban-Campistron , Françoise Desclaux , Colette Blatge , Thierry Dantoine , Cécile Laubarie-Mouret , Isabelle Saulnier , Jean-Pierre Clément , Marie-Agnès Picat , Laurence Bernard-Bourzeix , Stéphanie Willebois , Iléana Désormais , Noëlle Cardinaud , Marc Bonnefoy , Pierre Livet , Pascale Rebaudet , Claire Gédéon , Catherine Burdet , Flavien Terracol , Alain Pesce , Stéphanie Roth , Sylvie Chaillou , Sandrine Louchart , Kristelle Sudres , Nicolas Lebrun , Nadège Barro-Belaygues , Jacques Touchon , Karim Bennys , Audrey Gabelle , Aurélia Romano , Lynda Touati , Cécilia Marelli , Cécile Pays , Philippe Robert , Franck Le Duff , Claire Gervais , Sébastien Gonfrier , Yannick Gasnier , Serge Bordes , Danièle Begorre , Christian Carpuat , Khaled Khales , Jean-François Lefebvre , Samira Misbah El Idrissi , Pierre Skolil , Jean-Pierre Salles , Carole Dufouil , Stéphane Lehéricy , Marie Chupin , Jean-François Mangin , Ali Bouhayia , Michèle Allard , Frédéric Ricolfi , Dominique Dubois , Marie Paule Bonceour Martel , François Cotton , Alain Bonafé , Stéphane Chanalet , Françoise Hugon , Fabrice Bonneville , Christophe Cognard , François Chollet , Pierre Payoux , Thierry Voisin , Julien Delrieu (5, 2, 3) , Sophie Peiffer , Anne Hitzel , Michèle Allard , Michel Zanca , Jacques Monteil , Jacques Darcourt , Laurent Molinier (2, 15) , Hélène Derumeaux , Nadège Costa (15, 2) , Bertrand Perret , Claire Vinel , Sylvie Caspar-Bauguil , Pascale Olivier-Abbal , Sandrine Andrieu (7, 1, 16) , Christelle Cantet , Nicola Coley
Lauréane Brigitte
  • Function : Author
Catherine Faisant
  • Function : Author
Françoise Lala
  • Function : Author
Emeline Combrouze
  • Function : Author
Carole Badufle
  • Function : Author
Audrey Zueras
  • Function : Author
Françoise Lala
  • Function : Author
Francine Fontaine
  • Function : Author
Isabelle Marcet
  • Function : Author
Alexandra Foubert
  • Function : Author
Sandrine Cerda
  • Function : Author
Corinne Costes
  • Function : Author
Olivier Rouaud
  • Function : Author
Patrick Manckoundia
  • Function : Author
Valérie Quipourt
  • Function : Author
Sophie Marilier
  • Function : Author
Evelyne Franon
  • Function : Author
Lawrence Bories
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Marie-Laure Pader
  • Function : Author
Marie-France Basset
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Bruno Lapoujade
  • Function : Author
Valérie Faure
  • Function : Author
Michael Li Yung Tong
  • Function : Author
Christine Malick-Loiseau
  • Function : Author
Evelyne Cazaban-Campistron
  • Function : Author
Françoise Desclaux
  • Function : Author
Colette Blatge
  • Function : Author
Thierry Dantoine
  • Function : Author
Cécile Laubarie-Mouret
  • Function : Author
Isabelle Saulnier
  • Function : Author
Jean-Pierre Clément
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Marie-Agnès Picat
  • Function : Author
Laurence Bernard-Bourzeix
  • Function : Author
Stéphanie Willebois
  • Function : Author
Iléana Désormais
  • Function : Author
Noëlle Cardinaud
  • Function : Author
Marc Bonnefoy
  • Function : Author
Pierre Livet
  • Function : Author
Pascale Rebaudet
  • Function : Author
Claire Gédéon
  • Function : Author
Catherine Burdet
  • Function : Author
Flavien Terracol
  • Function : Author
Alain Pesce
  • Function : Author
Stéphanie Roth
  • Function : Author
Sylvie Chaillou
  • Function : Author
Sandrine Louchart
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Kristelle Sudres
  • Function : Author
Nicolas Lebrun
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Nadège Barro-Belaygues
  • Function : Author
Jacques Touchon
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Karim Bennys
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Audrey Gabelle
  • Function : Author
Aurélia Romano
  • Function : Author
Lynda Touati
  • Function : Author
Cécilia Marelli
  • Function : Author
Cécile Pays
  • Function : Author
Philippe Robert
  • Function : Author
Franck Le Duff
  • Function : Author
Claire Gervais
  • Function : Author
Sébastien Gonfrier
  • Function : Author
Yannick Gasnier
  • Function : Author
Serge Bordes
  • Function : Author
Danièle Begorre
  • Function : Author
Christian Carpuat
  • Function : Author
Khaled Khales
  • Function : Author
Jean-François Lefebvre
  • Function : Author
Samira Misbah El Idrissi
  • Function : Author
Pierre Skolil
  • Function : Author
Jean-Pierre Salles
  • Function : Author
Carole Dufouil
  • Function : Author
Stéphane Lehéricy
  • Function : Author
Marie Chupin
  • Function : Author
Jean-François Mangin
  • Function : Author
Ali Bouhayia
  • Function : Author
Michèle Allard
  • Function : Author
Frédéric Ricolfi
  • Function : Author
Dominique Dubois
  • Function : Author
Marie Paule Bonceour Martel
  • Function : Author
François Cotton
Alain Bonafé
  • Function : Author
Stéphane Chanalet
  • Function : Author
Françoise Hugon
  • Function : Author
Fabrice Bonneville
  • Function : Author
Christophe Cognard
  • Function : Author
François Chollet
  • Function : Author
Pierre Payoux
Thierry Voisin
  • Function : Author
Sophie Peiffer
  • Function : Author
Anne Hitzel
  • Function : Author
Michèle Allard
  • Function : Author
Michel Zanca
  • Function : Author
Jacques Monteil
  • Function : Author
Jacques Darcourt
  • Function : Author
Hélène Derumeaux
  • Function : Author
Bertrand Perret
  • Function : Author
Claire Vinel
  • Function : Author
Sylvie Caspar-Bauguil
  • Function : Author
Pascale Olivier-Abbal
  • Function : Author
Christelle Cantet
  • Function : Author
Nicola Coley
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Abstract

Abstract Background Weight and appetite regulation have been associated with the expression and secretion of ATPase inhibitory factor 1 (IF1) and growth differentiation factor-15 (GDF-15), 2 potential biomarkers for age-related mitochondrial dysfunction. The aim was to explore the associations between these biomarkers and nutritional variables in the Multidomain Alzheimer Preventive Trial study. Methods IF1 and GDF-15 plasma levels were quantified at 1-year follow-up. The nutritional status was measured using the Mini Nutritional Assessment (MNA) score variation between baseline and 1- and 2-year visits; appetite loss was extracted from the MNA. Bodyweight was measured every 6 months until the third year and then yearly until the fifth year of follow-up, and weight loss was established if the loss was greater than 5% or 10% within the past 6 or 12 months, respectively. Bidirectional associations of IF1 and GDF-15 levels with malnutrition, appetite, and weight loss were examined. The interactions between individual IF1 and GDF-15 with sex were explored. Results Four hundred and forty-eight participants had MNA data and 1 045 had weight loss data. All the associations between IF1 levels and the MNA score, appetite loss, and weight loss were nonsignificant. Higher GDF-15 levels were cross-sectionally associated with appetite loss at the first year of follow-up, and the GDF-15 highest quartile was associated with nearly 80% higher risks of weight loss over 4 years. Interactions between IF1 and GDF-15 levels, and between these 2 markers and sex were not significantly associated with the outcomes. Conclusions GDF-15 plasma levels were related to key malnutrition criteria.
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Dates and versions

hal-04485939 , version 1 (01-03-2024)

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Laetitia Lengelé, Yves Rolland, Laurent Martinez, Sophie Guyonnet, Angelo Parini, et al.. Longitudinal Associations Between ATPase Inhibitory Factor 1, Growth Differentiation Factor-15, and Nutritional Status in Older Adults From the MAPT Study. Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 2024, 79 (1), ⟨10.1093/gerona/glad236⟩. ⟨hal-04485939⟩
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