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Article Dans Une Revue Muscle & Nerve Année : 2014

Ultrasound assessment of the diaphragm: Preliminary study of a canine model of X‐linked myotubular myopathy

Aarti Sarwal
  • Fonction : Auteur
Michael Cartwright
  • Fonction : Auteur
Francis Walker
  • Fonction : Auteur
Erin Mitchell
  • Fonction : Auteur
Anna Buj-Bello
Alan Beggs
  • Fonction : Auteur
Martin Childers
  • Fonction : Auteur

Résumé

ABSTRACT Introduction : We tested the feasibility of using neuromuscular ultrasound for non‐invasive real‐time assessment of diaphragmatic structure and function in a canine model of X‐linked myotubular myopathy (XLMTM). Methods : Ultrasound images in 3 dogs [wild‐type (WT), n = 1; XLMTM untreated, n = 1; XLMTM post–AAV8‐mediated MTM1 gene replacement, n = 1] were analyzed for diaphragm thickness, change in thickness with respiration, muscle echogenicity, and diaphragm excursion amplitude during spontaneous breathing. Results : Quantitative parameters of diaphragm structure were different among the animals. WT diaphragm was thicker and less echogenic than the XLMTM control, whereas the diaphragm measurements of the MTM1‐treated XLMTM dog were comparable to those of the WT dog. Conclusions : This pilot study demonstrates the feasibility of using ultrasound for quantitative assessment of the diaphragm in a canine model. In the future, ultrasonography may replace invasive measures of diaphragm function in canine models and in humans for non‐invasive respiratory monitoring and evaluation of neuromuscular disease. Muscle Nerve 50: 607–609, 2014

Dates et versions

hal-04481686 , version 1 (28-02-2024)

Identifiants

Citer

Aarti Sarwal, Michael Cartwright, Francis Walker, Erin Mitchell, Anna Buj-Bello, et al.. Ultrasound assessment of the diaphragm: Preliminary study of a canine model of X‐linked myotubular myopathy. Muscle & Nerve, 2014, 50 (4), pp.607-609. ⟨10.1002/mus.24294⟩. ⟨hal-04481686⟩
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