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Communication Dans Un Congrès Année : 2022

Physical activity and hereditary cancer risk management : Life-course perspective study cases

Monica Aceti
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Maria Caiata-Zufferey
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Maria Katapodi
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Résumé

Facilitated access to genetic information makes it possible to determine whether an individual is a carrier of a disease-causing variant and to provide clinical management options to reduce disease risk. For pathogenic variants predisposing to early cancer onset, such as BRCA1 or BRCA2 genes, research indicates that up to 50% of individuals from affected families remain unaware of their predisposition, do not get tested, and do not benefit from risk reduction measures. Aim: We investigate the timing and social aspects - using the Life Course Perspective (LCP) – of decision-making processes leading to undergoing, deferring or foregoing Hereditary Breast and Ovarian Cancer (HBOC) genetic testing. Theoretical Framework: LCP addresses the biographical trajectories and life transitions of individuals in their socio-economic, historical, and cultural contexts (Burton-Jeangros et al., 2015). LCP (Hamilton, 2016) provides a comprehensive exploration of the experience of people living with a positive test result for a genetic mutation. The interactions between risk factors, resources in everyday life, as well as cultural and socioeconomic dispositions impact HBOC mutation risk management. Method: Ongoing qualitative analysis of interviews and focus groups conducted with 57 HBOC carriers from the Swiss CASCADE cohort. Discussion: First, having family members who had either a positive or negative experience (trauma) with cancer influences decisions. Second, long-term risk management and agency related to uncertainty are strongly linked to the dimensions of life in relation to couple formation, births, and parenthood issues. Third, genetic testing results can also impact "significant others" (Kenen et al., 2004) or any members with caregiving concerns and influence decision-making processes. The deciphering of the “best” time, as early as necessary, in interaction with social determinants, LCP and relational support for undergoing genetic testing would be helpful for genetic counseling practitioners to offer comprehensive HBOC cancer prevention advice. Bibliography: Burton-Jeangros C., Cullati S., Sacker A. and Blane D. (2015). A Life Course Perspective on Health Trajectories and Transitions, New York, Springer publisher, coll. « Life course research and social policies n°4 ». Hamilton R.J., Innella N.A. & Bounds D.T., (2016). The Life Course Perspective: a Guide for Genetic Counselors. J Genet Counsel 25, 44–48. Kenen R., Arden-Jones A., & Eeles R. (2004). Healthy women from suspected hereditary breast and ovarian cancer families: the significant others in their lives. European Journal of Cancer Care, 13, 169-179.

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Sociologie
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Dates et versions

hal-04478849 , version 1 (26-02-2024)

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  • HAL Id : hal-04478849 , version 1

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Monica Aceti, Maria Caiata-Zufferey, Maria Katapodi. Physical activity and hereditary cancer risk management : Life-course perspective study cases. 19th Biennal European Society for Health and Medical Sociology Conference (ESHMS), 25-27 August 2022, Forlì Campus of University of Bologna, Italy, Aug 2022, Forlì, Italy. ⟨hal-04478849⟩

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