Direct Comparison of [18F]F-DPA with [18F]DPA-714 and [11C]PBR28 for Neuroinflammation Imaging in the same Alzheimer’s Disease Model Mice and Healthy Controls - Archive ouverte HAL
Article Dans Une Revue Molecular Imaging and Biology Année : 2021

Direct Comparison of [18F]F-DPA with [18F]DPA-714 and [11C]PBR28 for Neuroinflammation Imaging in the same Alzheimer’s Disease Model Mice and Healthy Controls

Francisco López-Picón
  • Fonction : Auteur
Thomas Keller
  • Fonction : Auteur
Diana Bocancea
  • Fonction : Auteur
Jatta Helin
  • Fonction : Auteur
Anna Krzyczmonik
  • Fonction : Auteur
Semi Helin
  • Fonction : Auteur
Frédéric Dollé
  • Fonction : Auteur
Juha Rinne
  • Fonction : Auteur
Merja Haaparanta-Solin
  • Fonction : Auteur
Olof Solin
  • Fonction : Auteur

Résumé

Abstract Purpose In this study we compared the recently developed TSPO tracer [ 18 F]F-DPA, with [ 18 F]DPA-714 and [ 11 C]PBR28 by performing in vivo PET imaging on the same Alzheimer’s disease mouse model APP/PS1-21 (TG) and wild-type (WT) mice with all three radiotracers. Procedures To compare the radiotracer uptake, percentage of injected dose/mL (%ID/mL), standardized uptake value ratios to cerebellum (SUVR CB ), and voxel-wise analyses were performed. Results The peak uptake of [ 18 F]F-DPA was higher than 4.3% ID/mL, while [ 18 F]DPA-714 reached just over 3% ID/mL, and [ 11 C]PBR28 was over 4% ID/mL in only one brain region in the WT mice. The peak/60-min uptake ratios of [ 18 F]F-DPA were significantly higher ( p < 0.001) than those of [ 18 F]DPA-714 and [ 11 C]PBR28. The differences in [ 18 F]F-DPA SUVR CB between WT and TG mice were highly significant ( p < 0.001) in the three studied time periods after injection. [ 18 F]DPA-714 uptake was significantly higher in TG mice starting in the 20–40-min timeframe and increased thereafter, whereas [ 11 C]PBR28 uptake became significant at 10–20 min ( p < 0.05) . The voxel-wise analysis confirmed the differences between the radiotracers. Conclusions [ 18 F]F-DPA displays higher brain uptake, higher TG-to-WT SUVR CB ratios, and faster clearance than [ 18 F]DPA-714 and [ 11 C]PBR28, and could prove useful for detecting low levels of inflammation and allow for shorter dynamic PET scans.

Domaines

Radiochimie

Dates et versions

hal-04478381 , version 1 (26-02-2024)

Identifiants

Citer

Francisco López-Picón, Thomas Keller, Diana Bocancea, Jatta Helin, Anna Krzyczmonik, et al.. Direct Comparison of [18F]F-DPA with [18F]DPA-714 and [11C]PBR28 for Neuroinflammation Imaging in the same Alzheimer’s Disease Model Mice and Healthy Controls. Molecular Imaging and Biology, 2021, 24 (1), pp.157-166. ⟨10.1007/s11307-021-01646-5⟩. ⟨hal-04478381⟩
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