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N°Spécial De Revue/Special Issue Life Année : 2021

Exercising in Hypoxia and Other Stimuli: Heart Rate Variability and Ventilatory Oscillations

François Lhuissier
Aurélien Pichon
Nicolas Voituron
Jean-Paul Richalet
  • Fonction : Auteur

Résumé

Periodic breathing is a respiratory phenomenon frequently observed in patients with heart failure and in normal subjects sleeping at high altitude. However, until recently, periodic breathing has not been studied in wakefulness and during exercise. This review relates the latest findings describing this ventilatory disorder when a healthy subject is submitted to simultaneous physiological (exercise) and environmental (hypoxia, hyperoxia, hypercapnia) or pharmacological (acetazolamide) stimuli. Preliminary studies have unveiled fundamental physiological mechanisms related to the genesis of periodic breathing characterized by a shorter period than those observed in patients (11~12 vs. 30~60 s). A mathematical model of the respiratory system functioning under the aforementioned stressors corroborated these data and pointed out other parameters, such as dead space, later confirmed in further research protocols. Finally, a cardiorespiratory interdependence between ventilatory oscillations and heart rate variability in the low frequency band may partly explain the origin of the augmented sympathetic activation at exercise in hypoxia. These nonlinear instabilities highlight the intrinsic “homeodynamic” system that allows any living organism to adapt, to a certain extent, to permanent environmental and internal perturbations.

Dates et versions

hal-04477952 , version 1 (26-02-2024)

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Citer

Eric Hermand, François Lhuissier, Aurélien Pichon, Nicolas Voituron, Jean-Paul Richalet. Exercising in Hypoxia and Other Stimuli: Heart Rate Variability and Ventilatory Oscillations. Life, 11 (7), pp.625, 2021, Special Issue Cellular and Functional Response to Hypoxia, ⟨10.3390/life11070625⟩. ⟨hal-04477952⟩
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