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Article Dans Une Revue Veterinary Research Année : 2024

Variation in the affinity of three representative avian adenoviruses for the cellular coxsackievirus and adenovirus receptor

Yapeng Song
Mingyue Tao
  • Fonction : Auteur
Lin Liu
  • Fonction : Auteur
Yang Wang
  • Fonction : Auteur
Zhenchao Zhao
  • Fonction : Auteur
Zongmei Huang
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Wenming Gao
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Qiang Wei
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  • PersonId : 1356755

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Xinsheng Li
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  • PersonId : 1356756

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Résumé

AbstractAccording to previous studies, three representative avian adenoviral strains utilize coxsackievirus–adenovirus receptor (CAR) as a receptor and seem to exhibit diverse binding affinities and modes. Thus, further revealing the exact molecular mechanism underlying the interaction between different FAdVs and the attachment receptor CAR is necessary. In this study, we successfully solved the crystal structure of the FAdV-4 fiber1 knob at 1.6 Å resolution. The interaction between the fibre knob and different domains of CAR was verified by confocal microscopy, coimmunoprecipitation and surface plasmon resonance (SPR) analysis. The fibre knobs of the three representative fowl adenoviruses specifically recognized CAR domain 1 (D1), but the recognition of CAR domain 2 (D2) by chicken embryo lethal orphan (CELO) strains was weak. These results provide insights into the differences in adenovirus‒host cell interactions and have important implications for the exploration of viral invasion mechanisms.
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Dates et versions

hal-04476998 , version 1 (26-02-2024)

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Yapeng Song, Mingyue Tao, Lin Liu, Yang Wang, Zhenchao Zhao, et al.. Variation in the affinity of three representative avian adenoviruses for the cellular coxsackievirus and adenovirus receptor. Veterinary Research, 2024, 55 (1), pp.23. ⟨10.1186/s13567-024-01277-y⟩. ⟨hal-04476998⟩

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