Brain organoids for hypoxic-ischemic studies: from bench to bedside - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Cellular and Molecular Life Sciences Année : 2023

Brain organoids for hypoxic-ischemic studies: from bench to bedside

Résumé

Our current knowledge regarding the development of the human brain mostly derives from experimental studies on nonhuman primates, sheep, and rodents. However, these studies may not completely simulate all the features of human brain development as a result of species differences and variations in pre-and postnatal brain maturation. Therefore, it is important to supplement the in vivo animal models to increase the possibility that preclinical studies have appropriate relevance for potential future human trials. Three-dimensional brain organoid culture technology could complement in vivo animal studies to enhance the translatability of the preclinical animal studies and the understanding of brain-related disorders. In this review, we focus on the development of a model of hypoxic-ischemic (HI) brain injury using human brain organoids to complement the translation from animal experiments to human pathophysiology. We also discuss how the development of these tools provides potential opportunities to study fundamental aspects of the pathophysiology of HI-related brain injury including differences in the responses between males and females.
Fichier principal
Vignette du fichier
Gaston-Breton et al.pdf (1.07 Mo) Télécharger le fichier
Origine : Fichiers produits par l'(les) auteur(s)

Dates et versions

hal-04476109 , version 1 (24-02-2024)

Identifiants

Citer

Romane Gaston-Breton, Auriane Maïza Letrou, Rifat Hamoudi, Barbara Stonestreet, Aloïse Mabondzo. Brain organoids for hypoxic-ischemic studies: from bench to bedside. Cellular and Molecular Life Sciences, 2023, 80, pp.318. ⟨10.1007/s00018-023-04951-0⟩. ⟨hal-04476109⟩
5 Consultations
2 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More