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Poster De Conférence Année : 2023

Venom peptides: promising tools for lung cancer imaging

Résumé

Many cancers, and the non-small cell lung cancer (NSCLC) in particular, are associated with significant overexpression of various ion channels such as certain subtypes of sodium, calcium and potassium channels, pH-sensitive channels (ASICs for acid sensing ion channels) or nicotinic acetylcholine receptors. Activation of these ion channels plays an important role in the aggressiveness of cancer cell and tumor invasion, their overexpression seeming to be correlated with the appearance of metastases. Although imaging approaches (radiography, CT-scan for computed tomography scanning, PET-scan for positron emission tomography) are commonly used in the anatomical characterization of lung cancer, some limitations of these approaches require the development of new imaging probes more specific of overexpressed molecular targets in lung adenocarcinomas. Peptide toxins, which possess unique pharmacological properties, are well known to act selectively and with high affinity on certain overexpressed ion channels in cancer cells. Therefore, a promising solution towards the development of new imaging agents oflung cancer biomarkers appears to be the chemical synthesis of these toxins allowing them to be labelled by “click” chemistry using various fluorescent or radioactive probes.
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Dates et versions

hal-04474222 , version 1 (23-02-2024)

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  • HAL Id : hal-04474222 , version 1

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Romain Baudat, Evelyne Benoit, Mathilde Keck, Pascal Kessler, Charles Truillet, et al.. Venom peptides: promising tools for lung cancer imaging. Journées scientifiques croisées des programmes Focus Organoïdes sur Puce et Focus Biomarqueurs, Oct 2023, Gif-sur-Yvette, France. ⟨hal-04474222⟩
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