Leu-Enkephalin Lipid Prodrug Nanoparticles: Relationship between Nanoparticles’ Structure, Interaction with Bovine Serum Albumin, and Analgesic Activity - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Chemistry of Materials Année : 2024

Leu-Enkephalin Lipid Prodrug Nanoparticles: Relationship between Nanoparticles’ Structure, Interaction with Bovine Serum Albumin, and Analgesic Activity

Résumé

Recently, we proposed in a paper a novel nanomedicine approach based on a versatile bioconjugation linkage (amide, diglycolate, or acylal) between the Leu-enkephalin (LENK), an endogenous neuropeptide, and the squalene (SQ), a natural and biocompatible lipid. The nanoformulation of the resulting bioconjugates allowed the specific delivery of LENK into inflamed tissues for efficient pain control after their intravenous administration. However, the variability of the analgesic profiles exhibited by the three types of LENK-SQ nanoparticles (NPs) remains not well understood. This study investigates the influence of the LENK-SQ NP composition on their supramolecular organization and their interaction with blood proteins. To achieve this objective, a physicochemical study was carried out using complementary techniques such as dynamic light scattering (DLS), small/wide-angle X-ray and neutron scattering (SAXS-WAXS and SANS), and circular dichroism (CD). This study brought together some important information, allowing us to shed light on the crucial link between nanoparticles’ structure, stability, and analgesic activity.
Fichier sous embargo
Fichier sous embargo
0 2 4
Année Mois Jours
Avant la publication
mardi 2 juillet 2024
Fichier sous embargo
mardi 2 juillet 2024
Connectez-vous pour demander l'accès au fichier

Dates et versions

hal-04474053 , version 1 (05-03-2024)

Identifiants

Citer

Sinda Lepetre-Mouelhi, Alexandre Da Silva, Lucas Prades, Jiao Feng, Frank Wien, et al.. Leu-Enkephalin Lipid Prodrug Nanoparticles: Relationship between Nanoparticles’ Structure, Interaction with Bovine Serum Albumin, and Analgesic Activity. Chemistry of Materials, 2024, 36 (2), pp.694-707. ⟨10.1021/acs.chemmater.3c02070⟩. ⟨hal-04474053⟩
56 Consultations
1 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More