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Poster De Conférence Année : 2022

Prevalence of mutations within RamAR operon associated with cross resistance phenotype among ESBL Enterobacteriaceae isolated in intensive care units

Résumé

Enterobacteriaceae producing ESBL (ESBL-E) are a major public health problem leading to an increase of morbi-mortality. Enterobacteriaceae can adapt to their hosts and/or hospital environment through diverse mechanisms, in particular modification of efflux systems expression conferring resistance to a large panel of biocides. AcrAB-TolC is a resistance-nodulation-division (RND) pump, which is in part regulated by a two-component system: RamAR operon. Mutations in this operon drive to a pump over-expression leading to a cross-resistance (CR) phenotype regarding quinolones, tigecycline, chloramphenicol, temocillin as well as a higher tolerance to biliary salts and resistance to phagocytosis. The aim of the study was to determine the prevalence of the mutations inside the RamAR operon leading to a CR phenotype among ESBL-E isolated and sequenced in a French Teaching hospital.
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Dates et versions

hal-04473237 , version 1 (22-02-2024)

Identifiants

  • HAL Id : hal-04473237 , version 1

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Alice MICHEL, Bénédicte Langlois, Simon Le Hello, François Gravey. Prevalence of mutations within RamAR operon associated with cross resistance phenotype among ESBL Enterobacteriaceae isolated in intensive care units. 32nd European Congress of Clinical Microbiology and Infectious Diseases, Apr 2022, Lisbon, Portugal. ⟨hal-04473237⟩
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