Updating the Classification of Chronic Inflammatory Enteropathies in Dogs
Résumé
Chronic inflammatory enteropathies (CIEs) in dogs are currently classified based on
response to sequential treatment trials into food-responsive (FREs); antibiotic-responsive (AREs);
immunosuppressant-responsive (IREs); and non-responsive enteropathies (NREs). Recent studies
have reported that a proportion of NRE dogs ultimately respond to further dietary trials and are
subsequently misclassified. The FRE subset among CIEs is therefore probably underestimated.
Moreover, alterations in the gut microbiota composition and function (dysbiosis) have been shown
to be involved in CIE pathogenesis in recent research on dogs. Metronidazole and other antibiotics
that have been used for decades for dogs with AREs have been demonstrated to result in increased
antimicrobial resistance and deleterious effects on the gut microbiota. As a consequence, the clinical
approach to CIEs has evolved in recent years toward the gradual abandonment of the use of antibiotics
and their replacement by other treatments with the aim of restoring a diverse and functional gut
microbiota. We propose here to refine the classification of canine CIEs by replacing the AREs category
with a microbiota-related modulation-responsive enteropathies (MrMREs) category.
Origine : Fichiers éditeurs autorisés sur une archive ouverte