Catalytic Intermolecular C(sp3)–H Amination with Sulfamates for the Asymmetric Synthesis of Amines
Résumé
A practical catalytic asymmetric benzylic C(sp3)–H amination through the intermolecular insertion of a rhodium-bound nitrene species is reported. The reaction of various substrates (used as the limiting component) with the readily accessible sulfamate PfbsNH2 and the chiral rhodium(II) catalyst Rh2(S-tfptad)4 in the presence PhI(OPiv)2 can be performed on a multigram scale, affording the corresponding benzylic amines with high levels of efficiency and enantiocontrol. This process offers new opportunities for the asymmetric synthesis of amines.