Catalytic Intermolecular C(sp<sup>3</sup>)–H Amination with Sulfamates for the Asymmetric Synthesis of Amines - Archive ouverte HAL
Communication Dans Un Congrès Année : 2019

Catalytic Intermolecular C(sp3)–H Amination with Sulfamates for the Asymmetric Synthesis of Amines

Résumé

A practical catalytic asymmetric benzylic C(sp3)–H amination through the intermolecular insertion of a rhodium-bound nitrene species is reported. The reaction of various substrates (used as the limiting component) with the readily accessible sulfamate PfbsNH2 and the chiral rhodium(II) catalyst Rh2(S-tfptad)4 in the presence PhI(OPiv)2 can be performed on a multigram scale, affording the corresponding benzylic amines with high levels of efficiency and enantiocontrol. This process offers new opportunities for the asymmetric synthesis of amines.
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Dates et versions

hal-04471613 , version 1 (22-02-2024)

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Ali Nasrallah, Yanis Lazib, Vincent Boquet, Benjamin Darses, Philippe Dauban. Catalytic Intermolecular C(sp3)–H Amination with Sulfamates for the Asymmetric Synthesis of Amines. Séminaire Laboratoire de Synthèse Organique Ecole Polytechnique, Mar 2020, Palaiseau, France. ⟨10.1021/acs.oprd.9b00424⟩. ⟨hal-04471613⟩
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