The bidirectional effects between cognitive ability and brain morphology: A life course Mendelian randomization analysis - Archive ouverte HAL Accéder directement au contenu
Pré-Publication, Document De Travail Année : 2023

The bidirectional effects between cognitive ability and brain morphology: A life course Mendelian randomization analysis

Frauke Nees
  • Fonction : Auteur
Dimitri Papadopoulos Orfanos
  • Fonction : Auteur
Luise Poustka
  • Fonction : Auteur
Juliane Fröhner
  • Fonction : Auteur
Jeanne Winterer
  • Fonction : Auteur
Robert Whelan
  • Fonction : Auteur

Résumé

Abstract Introduction Little is understood about the dynamic interplay between brain morphology and cognitive ability across the life course. Additionally, most existing research has focused on global morphology measures such as estimated total intracranial volume, mean thickness, and total surface area. Methods Mendelian randomization was used to estimate the bidirectional effects between cognitive ability, global and regional measures of cortical thickness and surface area, estimated total intracranial volume, total white matter, and the volume of subcortical structures (N=37,864). Analyses were stratified for developmental periods (childhood, early adulthood, mid-to-late adulthood; age range: 8-81 years). Results The earliest effects were observed in childhood and early adulthood in the frontoparietal lobes. A bidirectional relationship was identified between higher cognitive ability, larger estimated total intracranial volume (childhood, mid-to-late adulthood) and total surface area (all life stages). A thicker posterior cingulate cortex and a larger surface area in the caudal middle frontal cortex and temporal pole were associated with greater cognitive ability. Contrary, a thicker temporal pole was associated with lower cognitive ability. Discussion Stable effects of cognitive ability on brain morphology across the life course suggests that childhood is potentially an important window for intervention.

Dates et versions

hal-04471118 , version 1 (21-02-2024)

Identifiants

Citer

Roxanna Korologou-Linden, Isabel Schuurmans, Charlotte Cecil, Tonya White, Tobias Banaschewski, et al.. The bidirectional effects between cognitive ability and brain morphology: A life course Mendelian randomization analysis. 2024. ⟨hal-04471118⟩
1 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More