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Article Dans Une Revue Cells Année : 2023

Zebrafish: A Model Deciphering the Impact of Flavonoids on Neurodegenerative Disorders

Kamel Mhalhel
Mirea Sicari
  • Fonction : Auteur
Lidia Pansera
  • Fonction : Auteur
Jincan Chen
Maria Levanti
  • Fonction : Auteur
Sepand Rastegar
Antonino Germanà
Giuseppe Montalbano

Résumé

Over the past century, advances in biotechnology, biochemistry, and pharmacognosy have spotlighted flavonoids, polyphenolic secondary metabolites that have the ability to modulate many pathways involved in various biological mechanisms, including those involved in neuronal plasticity, learning, and memory. Moreover, flavonoids are known to impact the biological processes involved in developing neurodegenerative diseases, namely oxidative stress, neuroinflammation, and mitochondrial dysfunction. Thus, several flavonoids could be used as adjuvants to prevent and counteract neurodegenerative disorders such as Alzheimer’s and Parkinson’s diseases. Zebrafish is an interesting model organism that can offer new opportunities to study the beneficial effects of flavonoids on neurodegenerative diseases. Indeed, the high genome homology of 70% to humans, the brain organization largely similar to the human brain as well as the similar neuroanatomical and neurochemical processes, and the high neurogenic activity maintained in the adult brain makes zebrafish a valuable model for the study of human neurodegenerative diseases and deciphering the impact of flavonoids on those disorders.

Dates et versions

hal-04470586 , version 1 (21-02-2024)

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Citer

Kamel Mhalhel, Mirea Sicari, Lidia Pansera, Jincan Chen, Maria Levanti, et al.. Zebrafish: A Model Deciphering the Impact of Flavonoids on Neurodegenerative Disorders. Cells, 2023, 12 (2), pp.252. ⟨10.3390/cells12020252⟩. ⟨hal-04470586⟩
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