The Cost of Metabolic Interactions in Symbioses between Insects and Bacteria with Reduced Genomes
Résumé
Current understanding of many animal-microbial symbioses involving unculturable bacterial symbionts with much-reduced genomes derives almost entirely from nonquantitative inferences from genome data. To overcome this limitation, we reconstructed multipartner metabolic models that quantify both the metabolic fluxes within and between three xylem-feeding insects and their bacterial symbionts. This revealed near-complete metabolic segregation between cooccurring bacterial symbionts, despite extensive metabolite exchange between each symbiont and the host, suggestive of strict host controls over the metabolism of its symbionts. We extended the model analysis to investigate metabolic costs. The positive relationship between symbiont genome size and the metabolic cost incurred by the host points to fitness benefits to the host of bearing symbionts with small genomes. The multicompartment metabolic models developed here can be applied to other symbioses that are not readily tractable to experimental approaches.
Domaines
Sciences du Vivant [q-bio]
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ankrah-et-al-2018-the-cost-of-metabolic-interactions-in-symbioses-between-insects-and-bacteria-with-reduced-genomes.pdf (2.75 Mo)
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Origine : Publication financée par une institution
Licence : CC BY - Paternité
Licence : CC BY - Paternité