Topical clonazepam in stomatodynia: a randomised placebo-controlled study - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Pain Année : 2004

Topical clonazepam in stomatodynia: a randomised placebo-controlled study

Résumé

Stomatodynia is characterised by a spontaneous burning pain in the oral mucosa without known cause or recognised treatment. The purpose of this double-blind, randomised, multicentre parallel group study was to evaluate the efficacy of the topical use of clonazepam. Forty-eight patients (4 men and 44 women, aged 65+/-2.1 years) were included, of whom 41 completed the study. The patients were instructed to suck a tablet of 1 mg of either clonazepam or placebo and hold their saliva near the pain sites in the mouth without swallowing for 3 min and then to spit. This protocol was repeated three times a day for 14 days. The intensity was evaluated by a 11-point numerical scale before the first administration and then after 14 days. Two weeks after the beginning of treatment, the decrease in pain scores was 2.4+/-0.6 and 0.6+/-0.4 in the clonazepam and placebo group, respectively (P = 0.014). Similar effects were obtained in an intent-to-treat analysis (P = 0.027). The blood concentration of clonazepam was similar whether it was measured 14 days after sucking a tablet three times a day or during the 5 h that followed sucking a single tablet (n = 5). It is hypothesised that clonazepam acts locally to disrupt the mechanism(s) underlying stomatodynia.

Domaines

Neurobiologie
Fichier non déposé

Dates et versions

hal-04468268 , version 1 (20-02-2024)

Identifiants

Citer

Christelle Gremeau-Richard, Alain Woda, Marie Louise Navez, Nadine Attal, Didier Bouhassira, et al.. Topical clonazepam in stomatodynia: a randomised placebo-controlled study. Pain, 2004, 108 (1), pp.51-57. ⟨10.1016/j.pain.2003.12.002⟩. ⟨hal-04468268⟩
5 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More