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Article Dans Une Revue Journal of Orofacial Pain Année : 2024

Steroid dysregulation and stomatodynia (burning mouth syndrome).

Thuan Dao
  • Fonction : Auteur
Christelle Gremeau-Richard

Résumé

Stomatodynia ( burning mouth syndrome) is characterized by a spontaneous, continuous burning pain felt in the oral mucosa typically of anxiodepressive menopausal women. Because there is no obvious organic cause, it is considered a nonspecific pain. This Focus Article proposes a hypothesis based on the following pathophysiological cascade: chronic anxiety or post traumatic stress leads to a dysregulation of the adrenal production of steroids. One consequence is a decreased or modified production of some major precursors for the neuroactive steroid synthesis occurring in the skin, mucosa, and nervous system. At menopause, the drastic fall of the other main precursor supply , the gonadal steroids, leads to a brisk alteration of the production of neuroactive steroids. This results in neurodegenerative alterations of small nerves fibers of the oral mucosa and /or some brain areas involved in oral somatic sensations. These neuropathic changes become irreversible and precipitate the burning pain, dysgeusia, and xerostomia associated with stomatodynia, which all involve thin nerve fibers.

Domaines

Neurobiologie
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Dates et versions

hal-04468112 , version 1 (20-02-2024)

Identifiants

  • HAL Id : hal-04468112 , version 1
  • PUBMED : 19639097

Citer

Alain Woda, Thuan Dao, Christelle Gremeau-Richard. Steroid dysregulation and stomatodynia (burning mouth syndrome).. Journal of Orofacial Pain, 2024, 23 (3), pp.202-10. ⟨hal-04468112⟩

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