High Amino Acid Intake in Early Life Is Associated With Systolic but Not Diastolic Arterial Hypertension at 5 Years of Age in Children Born Very Preterm - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Journal of the American Heart Association Année : 2024

High Amino Acid Intake in Early Life Is Associated With Systolic but Not Diastolic Arterial Hypertension at 5 Years of Age in Children Born Very Preterm

Jean-Christophe Roze
  • Fonction : Auteur
Justine Bacchetta
  • Fonction : Auteur
Alexandre Lapillonne
  • Fonction : Auteur
Farid Boudred
  • Fonction : Auteur
Jean-Charles Picaud
  • Fonction : Auteur
Laetitia Marchand-Martin
  • Fonction : Auteur
Alexandra Bruel-Tessoulin
  • Fonction : Auteur
Valerie Biran
  • Fonction : Auteur
Anne-Monique Nuyt
  • Fonction : Auteur
Dominique Darmaun
  • Fonction : Auteur
Pierre-Yves Ancel
  • Fonction : Auteur

Résumé

BACKGROUND: The life course of individuals born very premature is a topic of increasing concern. The association between high early amino acid intake and later high blood pressure (HBP) in preterm neonates is debated. METHODS AND RESULTS: In a national, prospective, population-based birth cohort, EPIPAGE-2 (Etude Epidémiologique sur Petits Ages Gestationnels), we assessed blood pressure at 5 years. Eligible infants were those born between 24 and 29 weeks of gestation. Infants were distributed in 2 groups of 717 infants matched on propensity score on whether or not they were exposed to high amino acid intake (>3.5 g/kg per day at day 7); 455 control term infants were also enrolled. A value ≥95th percentile of reference values for age and height defined systolic or diastolic HBP. Blood pressure at 5 years of age was assessed for 389 and 385 children in the exposed and nonexposed groups, respectively. Rates (in percent) of systolic and diastolic HBP were 18.0% (95% CI, 14.5%-22.2%), 13.3% (95% CI, 10.3%-17.0%), 8.5% (95% CI, 6.5%-11.1%), and 9.0% (95% CI, 6.6%-12.3%), 10.2% (95% CI, 7.5%-13.6%), and 5.4% (95% CI, 3.8%-7.6%) in exposed, nonexposed, and term-born groups, respectively. Exposure to high early amino acid intake and maximal serum creatinine (by 50 μmol/L) between day 3 and day 7 were 2 independent risk factors for systolic HBP (adjusted odds ratio [aOR], 1.60 [95% CI, 1.05-2.43] and aOR, 1.59 [95% CI, 1.12-2.26], respectively) but not for diastolic HBP (aOR, 0.84 [95% CI, 0.50-1.39] and aOR, 1.09 [95% CI, 0.71-1.67], respectively). After adjustment for 5-year weight Z score, the aOR between high early amino acid intake and systolic HBP was 1.50 [95% CI, 0.98-2.30]. CONCLUSIONS: These results suggest that mechanisms of childhood systolic HBP involve neonatal renal challenge by high amino acid intake or dysfunction.
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hal-04467383 , version 1 (20-02-2024)

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Paternité - Pas d'utilisation commerciale - Pas de modification

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Jean-Christophe Roze, Justine Bacchetta, Alexandre Lapillonne, Farid Boudred, Jean-Charles Picaud, et al.. High Amino Acid Intake in Early Life Is Associated With Systolic but Not Diastolic Arterial Hypertension at 5 Years of Age in Children Born Very Preterm. Journal of the American Heart Association, 2024, 13 (1), pp.e032804. ⟨10.1161/jaha.123.032804⟩. ⟨hal-04467383⟩
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