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Article Dans Une Revue Journal of Personalized Medicine Année : 2023

Toward a Systematic Assessment of Sex Differences in Cystic Fibrosis

Résumé

(1) Background: Cystic fibrosis (CF) is a disease with well-documented clinical differences between female and male patients. However, this gender gap is very poorly studied at the molecular level. (2) Methods: Expression differences in whole blood transcriptomics between female and male CF patients are analyzed in order to determine the pathways related to sex-biased genes and assess their potential influence on sex-specific effects in CF patients. (3) Results: We identify sex-biased genes in female and male CF patients and provide explanations for some sex-specific differences at the molecular level. (4) Conclusion: Genes in key pathways associated with CF are differentially expressed between sexes, and thus may account for the gender gap in morbidity and mortality in CF.
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Dates et versions

hal-04460883 , version 1 (15-02-2024)

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Christiane Gärtner, Jörg Fallmann, Peter F Stadler, Thorsten Kaiser, Sarah J Berkemer. Toward a Systematic Assessment of Sex Differences in Cystic Fibrosis. Journal of Personalized Medicine, 2023, 13 (6), pp.924. ⟨10.3390/jpm1010000⟩. ⟨hal-04460883⟩
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