The importance of naturally attenuated SARS‐CoV ‐2 in the fight against COVID ‐19 - Archive ouverte HAL
Article Dans Une Revue Environmental Microbiology Année : 2020

The importance of naturally attenuated SARS‐CoV ‐2 in the fight against COVID ‐19

Jean Armengaud (1, 2, 3) , Agnès Delaunay-Moisan (4) , Jean‐yves Thuret (5) , Eelco van Anken , Diego Acosta-Alvear (6, 7) , Tomás Aragón (8) , Carolina Arias (7) , Marc Blondel (9, 10) , Ineke Braakman (11) , Jean‐françois Collet (12) , René Courcol (13) , Antoine Danchin (14) , Jean‐françois Deleuze (15, 16) , Jean‐philippe Lavigne (17, 18) , Sophie Lucas (12, 19) , Thomas Michiels (12) , Edward Moore , Jonathon Nixon-Abell (20, 21) , Ramon Rossello-Mora (22) , Zheng‐li Shi , Antonio Siccardi , Roberto Sitia (23) , Daniel Tillett , Kenneth Timmis , Michel Toledano , Peter van der Sluijs , Elisa Vicenzi
1 MTS - Médicaments et Technologies pour la Santé
2 SPI - Service de Pharmacologie et Immunoanalyse
3 LI2D - Laboratoire Innovations technologiques pour la Détection et le Diagnostic
4 SOC - Stress Oxydatif et Cancer
5 I2BC - Institut de Biologie Intégrative de la Cellule
6 University of the Pacific [San Francisco]
7 UC Santa Barbara - University of California [Santa Barbara]
8 UPNA - Universidad Pública de Navarra [Espagne] = Public University of Navarra
9 GGB - Génétique, génomique fonctionnelle et biotechnologies (UMR 1078)
10 Hôpital Augustin Morvan
11 Cellular Protein Chemistry, Bijvoet Centre for Biomolecular Research, Utrecht University
12 UCL - Université Catholique de Louvain = Catholic University of Louvain
13 CHRU Lille - Centre Hospitalier Régional Universitaire [CHU Lille]
14 School of Biomedical Sciences
15 CNRGH - Centre National de Recherche en Génomique Humaine
16 Université Paris-Saclay
17 CHU Nîmes - Centre Hospitalier Universitaire de Nîmes
18 UM - Université de Montpellier
19 WELBIO - Walloon Excellence in Life sciences and BIOtechnology [Liège]
20 HHMI Janelia - Janelia Research Campus [Ashburn]
21 CIMR - Cambridge Institute for Medical Research
22 Mediterranean Institute for Advanced Studies
23 UniSR - Universita Vita Salute San Raffaele = Vita-Salute San Raffaele University [Milan, Italie]
Jean Armengaud
Médicaments et Technologies pour la Santé
Service de Pharmacologie et Immunoanalyse
Laboratoire Innovations technologiques pour la Détection et le Diagnostic
Agnès Delaunay-Moisan
  • Fonction : Auteur
Stress Oxydatif et Cancer
Jean‐yves Thuret
Institut de Biologie Intégrative de la Cellule
Eelco van Anken
Diego Acosta-Alvear
University of the Pacific [San Francisco]
University of California [Santa Barbara]
Tomás Aragón
Universidad Pública de Navarra [Espagne] = Public University of Navarra
Carolina Arias
University of California [Santa Barbara]
Marc Blondel
Génétique, génomique fonctionnelle et biotechnologies (UMR 1078)
Hôpital Augustin Morvan
Ineke Braakman
Cellular Protein Chemistry, Bijvoet Centre for Biomolecular Research, Utrecht University
Jean‐françois Collet
Université Catholique de Louvain = Catholic University of Louvain
René Courcol
Centre Hospitalier Régional Universitaire [CHU Lille]
Antoine Danchin
School of Biomedical Sciences
CV
Jean‐françois Deleuze
Centre National de Recherche en Génomique Humaine
Université Paris-Saclay
CV
Jean‐philippe Lavigne
Centre Hospitalier Universitaire de Nîmes
Université de Montpellier
Sophie Lucas
Université Catholique de Louvain = Catholic University of Louvain
Walloon Excellence in Life sciences and BIOtechnology [Liège]
Thomas Michiels
Université Catholique de Louvain = Catholic University of Louvain
Edward Moore
Jonathon Nixon-Abell
Janelia Research Campus [Ashburn]
Cambridge Institute for Medical Research
Ramon Rossello-Mora
Mediterranean Institute for Advanced Studies
Zheng‐li Shi
Antonio Siccardi
Roberto Sitia
Universita Vita Salute San Raffaele = Vita-Salute San Raffaele University [Milan, Italie]
Daniel Tillett
Kenneth Timmis
Michel Toledano
Peter van der Sluijs
Elisa Vicenzi

Résumé

The current SARS‐CoV‐2 pandemic is wreaking havoc throughout the world and has rapidly become a global health emergency. A central question concerning COVID‐19 is why some individuals become sick and others not. Many have pointed already at variation in risk factors between individuals. However, the variable outcome of SARS‐CoV‐2 infections may, at least in part, be due also to differences between the viral subspecies with which individuals are infected. A more pertinent question is how we are to overcome the current pandemic. A vaccine against SARS‐CoV‐2 would offer significant relief, although vaccine developers have warned that design, testing and production of vaccines may take a year if not longer. Vaccines are based on a handful of different designs (i), but the earliest vaccines were based on the live, attenuated virus. As has been the case for other viruses during earlier pandemics, SARS‐CoV‐2 will mutate and may naturally attenuate over time (ii). What makes the current pandemic unique is that, thanks to state‐of‐the‐art nucleic acid sequencing technologies, we can follow in detail how SARS‐CoV‐2 evolves while it spreads. We argue that knowledge of naturally emerging attenuated SARS‐CoV‐2 variants across the globe should be of key interest in our fight against the pandemic.

Domaines

Sciences du Vivant [q-bio]

Jean Armengaud  : Connectez-vous pour contacter le contributeur

https://hal.science/hal-04460462

Soumis le : jeudi 15 février 2024-17:44:40

Dernière modification le : mercredi 18 décembre 2024-10:38:02

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hal-04460462 , version 1 (15-02-2024)

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Jean Armengaud, Agnès Delaunay-Moisan, Jean‐yves Thuret, Eelco van Anken, Diego Acosta-Alvear, et al.. The importance of naturally attenuated SARS‐CoV ‐2 in the fight against COVID ‐19. Environmental Microbiology, 2020, 22 (6), pp.1997-2000. ⟨10.1111/1462-2920.15039⟩. ⟨hal-04460462⟩

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