Digital nomadism (DN), an emerging lifestyle based on remote working, digital technology and leisure travels, has grown from a marginal phenomenon concerning isolated individuals in the early 2000s to a mainstream movement. Even though official statistics are not available, recent reports show a steep rise in the number of digital nomads (DNs). In response to this growing trend, both public and private actors have launched new initiatives targeting DNs (e.g. dedicated visa schemes and coliving spaces), arguably transforming physical and digital environments to better respond to the specific needs of this cohort. Despite several initiatives to promote DN, little is known on the growing population of DNs, their nomadic lifestyles and spatial impacts. Grounded in the new mobilities paradigm, and based on a systematic literature review covering the last decade, this article explores DN from the perspective of (digital and physical) space and mobility. Findings show that space and mobility largely shape definitions of DN as well as how nomads perceive their identity and lifestyle, and also choose their destinations. Moreover, DN has many impacts on mobility and space, such as the need for specific infrastructures, and the contribution to gentrification in some urban areas. In the context of new post-pandemic work practices, research on DN is urgently needed.