Communication Dans Un Congrès Année : 2023

Characteristics of severe asthma patients included in the French Palomb Cohort

Résumé

Background: The prevalence of severe asthma among asthmatic patients is estimated between 5-10% in France. The aim of this work was to describe clinical features of patients included in the French Severe Asthma Palomb cohort. Methods: Patients followed in a real-life context by pulmonologists located in 2 regions since 2019. Inclusion criteria: 1) ⩾18 years-old, 2) >6 months follow-up before inclusion for severe asthma, (GINA, 2019) 3) combination of ICS and LABA and anticholinergic, associated with 4) OCS, anti-IgE based treatment, anti-IL5, anti-RIL5, anti-IL4, anti-IL13, thermoplasty. Results: In January 2023, 214 patients were included. Mean age was 55.1 years old (±16.4). 61.7% were female, 30.0% had a BMI⩾30 (morbid/severe obesity), 29.3% were previous smokers and 4.8% current smokers. 61.4% had an onset of asthma symptoms after the age of 15 and 21.8% had a history of acute severe asthma. 36.8% had dyspnea (mMRC⩾2) and 23.8% had chronic cough (>8 weeks). During the 12 months before inclusion, 25.2% had at least 2 exacerbations (having required a general corticotherapy or an increase in ICS treatment). 29.0% had chronic rhinitis, 22.9% gastro-esophageal reflux disease, 19.2% chronic rhinosinusitis, 14.0% anxiety, 13.6% blood hypertension and 13.1% sleep apnea syndrome. Regarding phenotypes: 46.0% were eosinophilic with allergy and 32.1% were eosinophilic without allergy. 135 patients were already on a biotherapy treatment at inclusion and 26 had a biotherapy introduced at inclusion. Conclusion: These are preliminary results of an observatory of patients followed with severe asthma in the French medical framework. Sponsors: Bordeaux University Foundation, AstraZeneca, Chiesi, GSK, Novartis, Sanofi.

Fichier non déposé

Dates et versions

hal-04459617 , version 1 (15-02-2024)

Identifiants

Citer

Nolwenn Jestin-Guyon, El Hassane Ouaalaya, Annaig Ozier, Cecilia Nocent, Alain Bernady, et al.. Characteristics of severe asthma patients included in the French Palomb Cohort. the ERS International Congress 2023, The European Respiratory Society (ERS), Sep 2023, Milan, Italy. pp.PA4432, ⟨10.1183/13993003.congress-2023.PA4432⟩. ⟨hal-04459617⟩
44 Consultations
0 Téléchargements

Altmetric

Partager

  • More