Pathophysiological pathway differences in children who present with COVID-19 ARDS compared to COVID -19 induced MIS-C - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Nature Communications Année : 2022

Pathophysiological pathway differences in children who present with COVID-19 ARDS compared to COVID -19 induced MIS-C

Tengyi Cai
  • Fonction : Auteur
Dominique Lasne
Jemma Wu
  • Fonction : Auteur
Thiri Zaw
  • Fonction : Auteur
Atul Bhatnagar
Suelyn van den Helm
Chantal Attard
Vasiliki Karlaftis
  • Fonction : Auteur
Paul Monagle
  • Fonction : Auteur

Résumé

Abstract COVID-19 has infected more than 275 million worldwide (at the beginning of 2022). Children appear less susceptible to COVID-19 and present with milder symptoms. Cases of children with COVID-19 developing clinical features of Kawasaki-disease have been described. Here we utilise Mass Spectrometry proteomics to determine the plasma proteins expressed in healthy children pre-pandemic, children with multisystem inflammatory syndrome (MIS-C) and children with COVID-19 induced ARDS. Pathway analyses were performed to determine the affected pathways. 76 proteins are differentially expressed across the groups, with 85 and 52 proteins specific to MIS-C and COVID-19 ARDS, respectively. Complement and coagulation activation are implicated in these clinical phenotypes, however there was significant contribution of FcGR and BCR activation in MIS-C and scavenging of haem and retinoid metabolism in COVID-19 ARDS. We show global proteomic differences in MIS-C and COVID-ARDS, although both show complement and coagulation dysregulation. The results contribute to our understanding of MIS-C and COVID-19 ARDS in children.

Domaines

Hématologie
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Dates et versions

hal-04457421 , version 1 (17-03-2024)

Identifiants

Citer

Conor Mccafferty, Tengyi Cai, Delphine Borgel, Dominique Lasne, Sylvain Renolleau, et al.. Pathophysiological pathway differences in children who present with COVID-19 ARDS compared to COVID -19 induced MIS-C. Nature Communications, 2022, 13 (1), pp.2391. ⟨10.1038/s41467-022-29951-9⟩. ⟨hal-04457421⟩
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