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Communication Dans Un Congrès Année : 2019

Numerical Assessment ff Device-Related Thrombus Formation Triggered by the Contact System

Résumé

Thrombosis is a major concern in blood-coated medical devices. In the present study, pro-coagulant reactions including the contact activation system are coupled with a fluid solver as well as a recently proposed thrombus formation model. The resulting biochemical/fluid model is applied to a backward facing step configuration, a flow configuration that frequently appears in medical devices. Simulations show that the contact system induces a large concentration of thrombin is the recirculation zone without the need of an a priori knowledge of the thrombus location. Platelets are then chemically activated and generate a thrombus whose both position and growth rate are in good agreement with the experimental data available.
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Dates et versions

hal-04456678 , version 1 (15-02-2024)

Identifiants

  • HAL Id : hal-04456678 , version 1

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Franck Nicoud, Rodrigo Méndez Rojano, Didier Lucor. Numerical Assessment ff Device-Related Thrombus Formation Triggered by the Contact System. 6th International Conference on Computational and Mathematical Biomedical Engineering – CMBE2019, 2019, Sendai, Japan. pp.75-78. ⟨hal-04456678⟩
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