Human Epitopes Identified from Herpes Simplex Virus Tegument Protein VP11/12 (UL46) Recall Multifunctional Effector Memory CD4 + T EM Cells in Asymptomatic Individuals and Protect from Ocular Herpes Infection and Disease in “Humanized” HLA-DR Transgenic Mice - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Journal of Virology Année : 2020

Human Epitopes Identified from Herpes Simplex Virus Tegument Protein VP11/12 (UL46) Recall Multifunctional Effector Memory CD4 + T EM Cells in Asymptomatic Individuals and Protect from Ocular Herpes Infection and Disease in “Humanized” HLA-DR Transgenic Mice

Ruchi Srivastava
  • Fonction : Auteur
Pierre-Gregoire Coulon
  • Fonction : Auteur
Swayam Prakash
  • Fonction : Auteur
Nisha Dhanushkodi
  • Fonction : Auteur
Soumyabrata Roy
  • Fonction : Auteur
Angela Nguyen
  • Fonction : Auteur
Nuha Alomari
  • Fonction : Auteur
Uyen Mai
  • Fonction : Auteur
Cassendra Amezquita
  • Fonction : Auteur
Caitlin Ye
  • Fonction : Auteur
Lbachir Benmohamed
  • Fonction : Auteur

Résumé

We report that naturally protected HSV-1-seropositive asymptomatic individuals develop a higher frequency of antiviral effector memory CD4 + T EM cells specific to two immunodominant epitopes derived from the HSV-1 tegument protein VP11/12. Immunization of HLA-DR transgenic mice with a mixture of these two immunodominant CD4 + T cell epitopes induced a robust antiviral CD4 + T cell response in the cornea that was associated with protective immunity against ocular herpes. The emerging concept of developing an asymptomatic herpes vaccine that would boost effector memory CD4 + and CD8 + T EM cell responses is discussed.

Domaines

Immunologie

Dates et versions

hal-04454718 , version 1 (13-02-2024)

Identifiants

Citer

Ruchi Srivastava, Pierre-Gregoire Coulon, Swayam Prakash, Nisha Dhanushkodi, Soumyabrata Roy, et al.. Human Epitopes Identified from Herpes Simplex Virus Tegument Protein VP11/12 (UL46) Recall Multifunctional Effector Memory CD4 + T EM Cells in Asymptomatic Individuals and Protect from Ocular Herpes Infection and Disease in “Humanized” HLA-DR Transgenic Mice. Journal of Virology, 2020, 94 (7), ⟨10.1128/JVI.01991-19⟩. ⟨hal-04454718⟩
21 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More