Temporal Evaluation of the Surface Area of Treated Skin Ulcers Caused by Cutaneous Leishmaniasis and Relation with Optical Parameters in an Animal Model: A Proof of Concept - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Sensors Année : 2023

Temporal Evaluation of the Surface Area of Treated Skin Ulcers Caused by Cutaneous Leishmaniasis and Relation with Optical Parameters in an Animal Model: A Proof of Concept

Sergio Londoño
  • Fonction : Auteur
Carolina Viloria
  • Fonction : Auteur
Sandra Pérez-Buitrago
Javier Murillo
  • Fonction : Auteur
Artur Zarzycki
  • Fonction : Auteur
Johnson Garzón
  • Fonction : Auteur
Maria Torres-Madronero
Sara Robledo
Franck Marzani
Benjamin Castaneda
July Galeano
  • Fonction : Auteur

Résumé

Cutaneous leishmaniasis (CL) is a neglected disease caused by an intracellular parasite of the Leishmania genus. CL lacks tools that allow its understanding and treatment follow-up. This article presents the use of metrical and optical tools for the analysis of the temporal evolution of treated skin ulcers caused by CL in an animal model. Leishmania braziliensis and L. panamensis were experimentally inoculated in golden hamsters, which were treated with experimental and commercial drugs. The temporal evolution was monitored by means of ulcers’ surface areas, as well as absorption and scattering optical parameters. Ulcers’ surface areas were obtained via photogrammetry, which is a procedure that allowed for 3D modeling of the ulcer using specialized software. Optical parameters were obtained from a spectroscopy study, representing the cutaneous tissue’s biological components. A one-way ANOVA analysis was conducted to identify relationships between both the ulcers’ areas and optical parameters. As a result, ulcers’ surface areas were found to be related to the following optical parameters: epidermis thickness, collagen, keratinocytes, volume-fraction of blood, and oxygen saturation. This study is a proof of concept that shows that optical parameters could be associated with metrical ones, giving a more reliable concept during the assessment of a skin ulcer’s healing.

Dates et versions

hal-04454563 , version 1 (13-02-2024)

Identifiants

Citer

Sergio Londoño, Carolina Viloria, Sandra Pérez-Buitrago, Javier Murillo, Deivid Botina, et al.. Temporal Evaluation of the Surface Area of Treated Skin Ulcers Caused by Cutaneous Leishmaniasis and Relation with Optical Parameters in an Animal Model: A Proof of Concept. Sensors, 2023, 23 (13), pp.5861. ⟨10.3390/s23135861⟩. ⟨hal-04454563⟩
10 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More