At present, there is no effective and sustainable treatment to remove organic micropollutants from wastewater. Solar photo-oxidation offers the possibility of a self-sustaining, energetically and ecologically compatible process based solely on the use of solar energy for treatment operations. The main scientific challenge is to operate a photoreactor in continuous mode using the solar resource, which is by nature discontinuous. To date, daily or monthly capacities have not been established. This study focuses on a photoreactor operating in continuous mode under natural solar irradiation conditions for the treatment of substances contained in wastewater. Two reactors of the flat panel and tubular type, as well as a new configuration of the pool type, were studied in order to identify the advantages and disadvantages of each reactor. The main focus of the study is on a continuously operating solar photoreactor for the treatment of wastewater containing a very wide range of substances. Using a global approach, the substances were classified according to their capacity to be degraded in order to highlight the conditions necessary to conduct a photo-oxidation treatment operation. The daily capacities and the efficiency of photo-oxidation carried out continuously under dynamic irradiation conditions were established.