Optimization of the Synthesis of Diclofenac Derivatives with Hydrazone Structure and In Vitro Evaluation of the Anti-Inflammatory Potential - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Revista de Chimie Année : 2020

Optimization of the Synthesis of Diclofenac Derivatives with Hydrazone Structure and In Vitro Evaluation of the Anti-Inflammatory Potential

Alin Focsa
  • Fonction : Auteur
Andreea Iacob
  • Fonction : Auteur
Ioana Vasincu
  • Fonction : Auteur
Sandra Constantin
  • Fonction : Auteur
Loredana Andriescu
  • Fonction : Auteur
Alexandru Sava
  • Fonction : Auteur
Maria Apotrosoaei
  • Fonction : Auteur
Lenuta Profire
  • Fonction : Auteur

Résumé

The aim of the study was to optimize the synthesis of diclofenac derivative with hydrazones structure in order to obtain higher yields and purity by variation of different parameters such as: ratio between reactants, solvent, catalyst, temperature, time of reaction and method used. The anti-inflammatory effects of diclofenac derivatives were evaluated using in vitro assays: albumin denaturation and erythrocyte membrane stability. The obtained results showed that the effect of the tested derivatives is increasing with the concentration, the best results being obtained at the concentration of 125 �g/mL (albumin denaturation assay), respectively 111.11 �g/mL (erythrocyte membrane stability assay). The most active compound was 4d which showed the highest inhibition effect on albumin denaturation and an appreciable effect on erythrocyte membrane stability, in comparation with diclofenac, used as drug reference.

Dates et versions

hal-04451430 , version 1 (11-02-2024)

Identifiants

Citer

Alin Focsa, Andreea Iacob, Ioana Vasincu, Sandra Constantin, Loredana Andriescu, et al.. Optimization of the Synthesis of Diclofenac Derivatives with Hydrazone Structure and In Vitro Evaluation of the Anti-Inflammatory Potential. Revista de Chimie, 2020, 71 (5), pp.305-314. ⟨10.37358/RC.20.5.8138⟩. ⟨hal-04451430⟩
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