Access to Mono‐, Di‐ and Tri‐(Het)Arylated Pyrazolo[5,1‐ b ]oxazoles Using Cyclization, C−H Activation and Suzuki–Miyaura Palladium‐Catalyzed Reactions - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue European Journal of Organic Chemistry Année : 2023

Access to Mono‐, Di‐ and Tri‐(Het)Arylated Pyrazolo[5,1‐ b ]oxazoles Using Cyclization, C−H Activation and Suzuki–Miyaura Palladium‐Catalyzed Reactions

Résumé

Abstract A first access to mono‐, di‐ and tri‐(Het)arylated pyrazolo[5,1‐ b ]oxazoles is reported. The series were generated from a library of 3‐(Het)arylpyrazolo[5,1‐ b ]oxazole platforms selectively functionalized through regioselective arylation procedures. The regioselective functionalization in C ‐2 and C ‐7 positions was investigated. Each Palladium‐catalyzed cross‐coupling condition was optimized and a representative library of the scope and limitations of the reactions was studied.
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Dates et versions

hal-04451382 , version 1 (11-02-2024)

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Marion Michel, Flore Caré, Stéphane Bourg, Stéphane Bostyn, Pierre Lafite, et al.. Access to Mono‐, Di‐ and Tri‐(Het)Arylated Pyrazolo[5,1‐ b ]oxazoles Using Cyclization, C−H Activation and Suzuki–Miyaura Palladium‐Catalyzed Reactions. European Journal of Organic Chemistry, 2023, 27 (1), ⟨10.1002/ejoc.202301040⟩. ⟨hal-04451382⟩
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