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Article Dans Une Revue Journal of Bone and Mineral Research Année : 2020

Poor Bone Quality is Associated With Greater Arterial Stiffness: Insights From the UK Biobank

Zahra Raisi-Estabragh
Luca Biasiolli
Nay Aung
  • Fonction : Auteur
José Paiva
Mihir Sanghvi
  • Fonction : Auteur
Ross Thomson
Jennifer Rayner
  • Fonction : Auteur
Konrad Werys
  • Fonction : Auteur
Henrike Puchta
  • Fonction : Auteur
Katharine Thomas
  • Fonction : Auteur
Aaron Lee
  • Fonction : Auteur
Stefan Piechnik
  • Fonction : Auteur
Patricia Munroe
Cyrus Cooper

Résumé

ABSTRACT Osteoporosis and ischemic heart disease (IHD) represent important public health problems. Existing research suggests an association between the two conditions beyond that attributable to shared risk factors, with a potentially causal relationship. In this study, we tested the association of bone speed of sound (SOS) from quantitative heel ultrasound with (i) measures of arterial compliance from cardiovascular magnetic resonance (aortic distensibility [AD]); (ii) finger photoplethysmography (arterial stiffness index [ASI]); and (iii) incident myocardial infarction and IHD mortality in the UK Biobank cohort. We considered the potential mediating effect of a range of blood biomarkers and cardiometabolic morbidities and evaluated differential relationships by sex, menopause status, smoking, diabetes, and obesity. Furthermore, we considered whether associations with arterial compliance explained association of SOS with ischemic cardiovascular outcomes. Higher SOS was associated with lower arterial compliance by both ASI and AD for both men and women. The relationship was most consistent with ASI, likely relating to larger sample size available for this variable (n = 159,542 versus n = 18,229). There was no clear evidence of differential relationship by menopause, smoking, diabetes, or body mass index (BMI). Blood biomarkers appeared important in mediating the association for both men and women, but with different directions of effect and did not fully explain the observed effects. In fully adjusted models, higher SOS was associated with significantly lower IHD mortality in men, but less robustly in women. The association of SOS with ASI did not explain this observation. In conclusion, our findings support a positive association between bone and vascular health with consistent patterns of association in men and women. The underlying mechanisms are complex and appear to vary by sex. © 2020 The Authors. Journal of Bone and Mineral Research published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research (ASBMR).

Dates et versions

hal-04445091 , version 1 (07-02-2024)

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Citer

Zahra Raisi-Estabragh, Luca Biasiolli, Jackie Cooper, Nay Aung, Kenneth Fung, et al.. Poor Bone Quality is Associated With Greater Arterial Stiffness: Insights From the UK Biobank. Journal of Bone and Mineral Research, 2020, 36 (1), pp.90-99. ⟨10.1002/jbmr.4164⟩. ⟨hal-04445091⟩
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