The Relationships Between Serum Sclerostin, Bone Mineral Density, and Vascular Calcification in Rheumatoid Arthritis - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Journal of Clinical Endocrinology and Metabolism Année : 2014

The Relationships Between Serum Sclerostin, Bone Mineral Density, and Vascular Calcification in Rheumatoid Arthritis

Résumé

Context: Recent data indicate that the secreted glycoprotein sclerostin may be involved in vascular calcification (VC). Objective: The objective of the study was to establish whether serum sclerostin levels are associated with VC in patients with rheumatoid arthritis (RA). Design: This was a cross-sectional study. Setting: The study was conducted with ambulatory care. Patients: We compared 75 RA patients with 75 age- and gender-matched control participants. Intervention: Coronary artery calcification (CAC) and abdominal aortic calcification (AAC) scores were evaluated by computed tomography. Main Outcome Measure: Serum sclerostin levels (determined with an ELISA) were assessed. A statistical analysis was performed to identify the determinants of serum sclerostin and VC. Results: AAC and CAC were more prevalent and more severe in patients with RA than in controls. Higher levels of AAC (P = .02) and a higher lumbar bone mineral density (BMD; P = .03) were identified as independent determinants of higher serum sclerostin levels in RA patients, whereas male gender (P = .03), higher lumbar BMD (P < .0001), and low estimated glomerular rate (P < .001) were identified as determinants in controls. In RA patients, a multivariate logistic regression analysis indicated that older age [P < .01, with an odds ratio (OR) per year 1.10] and male gender (P = .02, OR 6.79) were independent determinants of CAC and that older age (P < .001, OR 1.16) were independent determinants of AAC. In controls, the independent determinants were older age (P < .01, OR 1.19), hypertension (P < .01, OR 7.31), and lumbar BMD (P = .03, OR per 30 mg/cm2 increment of 1.14) for CAC and older age (P = .01, OR 1.11) for AAC. Conclusions: Serum sclerostin levels were significantly and independently associated with AAC in RA patients.

Dates et versions

hal-04444980 , version 1 (07-02-2024)

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Julien Paccou, R. Mentaverri, C. Renard, S. Liabeuf, P. Fardellone, et al.. The Relationships Between Serum Sclerostin, Bone Mineral Density, and Vascular Calcification in Rheumatoid Arthritis. Journal of Clinical Endocrinology and Metabolism, 2014, 99 (12), pp.4740-4748. ⟨10.1210/jc.2014-2327⟩. ⟨hal-04444980⟩
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