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Article Dans Une Revue Molecular & Cellular Oncology Année : 2017

Re-investigating PLK1 inhibitors as antimitotic agents

Résumé

Polo-like kinase 1 (PLK1) plays key roles during mitosis, prompting the development of PLK1 inhibitors for anticancer therapy. We recently determined that PLK1 is crucially required for entry into mitosis. Hence, we discuss the potential and limitations of PLK1 inhibition strategies to promote mitotic arrest and death of cancer cells.
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Origine : Publication financée par une institution
Licence : CC BY NC ND - Paternité - Pas d'utilisation commerciale - Pas de modification

Dates et versions

hal-04444437 , version 1 (07-02-2024)

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Quentin Delacour, Olivier Gavet. Re-investigating PLK1 inhibitors as antimitotic agents. Molecular & Cellular Oncology, 2017, 4 (6), pp.e1356430. ⟨10.1080/23723556.2017.1356430⟩. ⟨hal-04444437⟩
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