The recent publication of documents and the comparison of new prosopographic material on the family of Appius Alexander, known to have been procurator of Asia and then governor of Lugdunensis in the middle of the 3rd century, provide an opportunity to reflect on the family ties and career steps of all those presently known to have been involved. Between Africa and Asia, a history of their matrimonial alliances, land ownership, and finally of their ascension in the ranks of the municipal notables and in the imperial aristocracy, emerges across several generations. One can bring to light the interprovincial relationships between the Carthaginian and Ephesian élites, and situate this family, which included Appius Sabinus, prefect of Egypt who became corrector of Asia, among the senatorial families of that period in this province. Also discussed is the administrative history of Asia in the middle of the 3rd century.